A4GNT transfers GlcNAc to core 2 mucins

Stable Identifier
R-HSA-5694487
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT) can catalyse the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched mucins, creating an alpha1,4-linkage with beta-Gal residues (arbitrarily named Core 2a mucins) (Nakayama et al. 1999, Zhang et al. 2001).

Literature References
PubMed ID Title Journal Year
10430883 Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin

Nakayama, J, Yeh, JC, Misra, AK, Ito, S, Katsuyama, T, Fukuda, M

Proc. Natl. Acad. Sci. U.S.A. 1999
11304796 Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa

Zhang, MX, Nakayama, J, Hidaka, E, Kubota, S, Yan, J, Ota, H, Fukuda, M

J. Histochem. Cytochem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetylglucosaminyltransferase activity of A4GNT [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created