ABHD10 hydrolyses MPAG

Stable Identifier
R-HSA-5694563
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant drug mycophenolate mofetil (MMF) and is primarily metabolised by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AMPAG), a potential immunotoxic metabolite. Mitochondrial mycophenolic acid acyl-glucuronide esterase (ABHD10) deglucuronidates AMPAG thereby ABHD10 could play a role in the protection against acyl glucuronide-induced toxicity (Iwamura et al. 2012).

Literature References
PubMed ID Title Journal Year
22294686 Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver

Iwamura, A, Fukami, T, Higuchi, R, Nakajima, M, Yokoi, T

J. Biol. Chem. 2012
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hasEvent
Catalyst Activity
Catalyst Activity
Title
hydrolase activity, hydrolyzing O-glycosyl compounds of ABHD10 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
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