ABHD10 hydrolyses MPAG

Stable Identifier
R-HSA-5694563
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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ABHD10 hydrolyses MPAG
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Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant drug mycophenolate mofetil (MMF) and is primarily metabolised by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AMPAG), a potential immunotoxic metabolite. Mitochondrial mycophenolic acid acyl-glucuronide esterase (ABHD10) deglucuronidates AMPAG thereby ABHD10 could play a role in the protection against acyl glucuronide-induced toxicity (Iwamura et al. 2012).

Literature References
PubMed ID Title Journal Year
22294686 Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver

Nakajima, M, Iwamura, A, Fukami, T, Yokoi, T, Higuchi, R

J. Biol. Chem. 2012
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Catalyst Activity

hydrolase activity, hydrolyzing O-glycosyl compounds of ABHD10 [mitochondrial matrix]

Physical Entity
ABHD10 [mitochondrial matrix] (Homo sapiens)
Activity
hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
Orthologous Events
ABHD10 hydrolyses MPAG (Bos taurus)
ABHD10 hydrolyses MPAG (Canis familiaris)
ABHD10 hydrolyses MPAG (Danio rerio)
ABHD10 hydrolyses MPAG (Gallus gallus)
ABHD10 hydrolyses MPAG (Mus musculus)
ABHD10 hydrolyses MPAG (Rattus norvegicus)
ABHD10 hydrolyses MPAG (Sus scrofa)
ABHD10 hydrolyses MPAG (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-22)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-22)
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