Reactome | ABHD4 hydrolyses NAPE

ABHD4 hydrolyses NAPE

Stable Identifier

R-HSA-5694583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Abhydrolase domain-containing protein 4 (ABHD4) is a regulator of endocannabinoid signalling and suppressor of tumor growth. Its physiological substrates are both N-acyl phosphatidylethanolamine (NAPE) and a wide range of lysoNAPEs. Shown here, ANHD4 mediates the hydrolysis of NAPE to glycerophospho-arachidonyl ethanolamine (GPAEA), an endocannabanoid (Simon & Cravatt 2006).

Literature References

PubMed ID	Title	Journal	Year
16818490	Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway Simon, GM, Cravatt, BF	J. Biol. Chem.	2006