ACSF3 ligates CoA-SH to VLCFA

Stable Identifier
R-HSA-5696007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 3 (ACSF3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA), around C24 in length (Watkins et al. 2007).

Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Watkins, PA, Maiguel, D, Jia, Z, Pevsner, J

J. Lipid Res. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
very long-chain fatty acid-CoA ligase activity of ACSF3 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created