ACSF3 ligates CoA-SH to VLCFA

Stable Identifier
R-HSA-5696007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 3 (ACSF3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA), around C24 in length (Watkins et al. 2007).
Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D

J. Lipid Res. 2007
Participants
Participates
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of ACSF3 [mitochondrial matrix]

Orthologous Events
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