Reactome | ADPGK:Mg2+ phosphorylates Glc to G6P

ADPGK:Mg2+ phosphorylates Glc to G6P

Stable Identifier

R-HSA-5696021

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22219026	Expression and role in glycolysis of human ADP-dependent glucokinase Stowell, KM, Richter, S, Richter, JP, Sutherland-Smith, AJ, Mehta, SY, Wilson, WR, Ronimus, RS, Print, CG, Gribble, AM	Mol. Cell. Biochem.	2012
23168256	T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation Gülow, K, Grigaravičius, P, Opp, S, Ruppert, T, Grudnik, P, Kamiński, MM, Gröne, HJ, Sauer, SW, Kamiński, M, Krammer, PH	Cell Rep	2012