ADPGK:Mg2+ phosphorylates Glc to G6P

Stable Identifier
R-HSA-5696021
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).

Literature References
PubMed ID Title Journal Year
23168256 T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

Kami?ski, MM, Sauer, SW, Kami?ski, M, Opp, S, Ruppert, T, Grigaravi?ius, P, Grudnik, P, Gröne, HJ, Krammer, PH, Gülow, K

Cell Rep 2012
22219026 Expression and role in glycolysis of human ADP-dependent glucokinase

Richter, S, Richter, JP, Mehta, SY, Gribble, AM, Sutherland-Smith, AJ, Stowell, KM, Print, CG, Ronimus, RS, Wilson, WR

Mol. Cell. Biochem. 2012
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ADP-specific glucokinase activity of ADPGK:Mg2+ [extracellular region]
Physical Entity
Activity
Orthologous Events
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Reviewed