ALDH3B1 oxidises HXAL to PALM

Stable Identifier
R-HSA-5696080
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Aldehyde dehydrogenases (ALDHs) detoxify toxic aldehydes by oxidation to the corresponding carboxylic acids. Long-chain aliphatic aldehydes are largely produced by catabolic metabolism of several lipids, including ether glycerolipids, fatty alcohols, sphingolipids and wax esters. Some medium-chain aliphatic aldehydes, such as hexanal, octanal and 4-hydroxy-2-nonenal (4HNE) are produced via lipid peroxidation during oxidative stress. Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) is able to oxidise both medium- and long-chain aldehydes. C16 aldehydes such as hexadecanal (HXAL) generated through sphingolipid metabolism on the plasma membrane can be oxidised to palmitic acid (PALM) (Kitamura et al. 2013). 4HNE, amongst other reactive medium-chain aldehydes, can be detoxified by oxidation to 4-hydroxynonenoic acid (4HNA) by ALDH3B1, suggesting a potential physiological role for ALDH3B1 against oxidative stress (not shown here) (Marchitti et al. 2010).

Literature References
PubMed ID Title Journal Year
20699116 Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress

Marchitti, SA, Brocker, C, Orlicky, DJ, Vasiliou, V

Free Radic. Biol. Med. 2010
23721920 Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1

Kitamura, T, Naganuma, T, Abe, K, Nakahara, K, Ohno, Y, Kihara, A

Biochim. Biophys. Acta 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase [NAD(P)+] activity of ALDH3B1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created