ALDH1B1 tetramer oxidises CH3CHO to CH3COOH

Stable Identifier
R-HSA-5696091
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ethanol-induced organ damage is attributed to its toxic metabolite acetaldehyde (CH3CHO) therefore metabolism and elimination of this metabolite is important for cellular defence. Mitochondrial ALDH1B1 is one of several human ALDHs that can oxidise CH3CHO to acetic acid (CH3COOH) (Stagos et al. 2010). ALDH1B1 is thought to function as a homotetramer.

Literature References
PubMed ID Title Journal Year
20616185 Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

Stagos, D, Chen, Y, Brocker, C, Donald, E, Jackson, BC, Orlicky, DJ, Thompson, DC, Vasiliou, V

Drug Metab. Dispos. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase (NAD) activity of ALDH1B1 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created