AGMO cleaves alkylglycerol into fatty aldehyde and glycerol

Stable Identifier
R-HSA-5696119
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ether lipids (alkylglycerols, glyceryl ethers) are essential components of brain membranes, protect the eye from cataract, mediate signalling processes and are required for spermatogenesis. Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin-dependent protein and is the only enzyme known to cleave the ether bond of alkylglycerols and lyso-alkylglycerol phospholipids into fatty aldehydes and glycerol derivatives (Watschinger et al. 2010).

Literature References
PubMed ID Title Journal Year
20643956 Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes

Watschinger, K, Keller, MA, Golderer, G, Hermann, M, Maglione, M, Sarg, B, Lindner, HH, Hermetter, A, Werner-Felmayer, G, Konrat, R, Hulo, N, Werner, ER

Proc. Natl. Acad. Sci. U.S.A. 2010
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Catalyst Activity
Title
glyceryl-ether monooxygenase activity of AGMO [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created