AOC2 deaminates TYR

Stable Identifier
R-HSA-5696146
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Retina-specific copper amine oxidase (AOC2) is present on the cell surface of most cells but especially retinal cells. It is classed as a semicarbazide-sensitive amine oxidase (SSAO) and catalyses the oxidative deamination of aromatic amines such as tyramine (TYR, shown here), 2-phenylethylamine and tryptamine (Kaitaniemi et al. 2009, Bour et al. 2007). Overexpression of AOC2 could result in tissue destruction seen in ocular pathologies.

Literature References
PubMed ID Title Journal Year
17400359 Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes

Bour, S, Daviaud, D, Gres, S, Lefort, C, Prévot, D, Zorzano, A, Wabitsch, M, Saulnier-Blache, JS, Valet, P, Carpéné, C

Biochimie 2007
19588076 The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase

Kaitaniemi, S, Elovaara, H, Grön, K, Kidron, H, Liukkonen, J, Salminen, T, Salmi, M, Jalkanen, S, Elima, K

Cell. Mol. Life Sci. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
primary amine oxidase activity of AOC2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created