NUDT2 hydrolyses GP4G to GTP, GMP

Stable Identifier
R-HSA-5696197
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity of NUDT2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Cross References
Rhea