NUDT2 hydrolyses GP4G to GTP, GMP

Stable Identifier
R-HSA-5696197
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).

Literature References
PubMed ID Title Journal Year
15596429 Structure and substrate-binding mechanism of human Ap4A hydrolase

Swarbrick, JD, Buyya, S, Gunawardana, D, Gayler, KR, McLennan, AG, Gooley, PR

J. Biol. Chem. 2005
7487923 Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases

Thorne, NM, Hankin, S, Wilkinson, MC, Nuņez, C, Barraclough, R, McLennan, AG

Biochem. J. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity of NUDT2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed