AS3MT transfers CH3 from AdoMet to arsenite(3-)

Stable Identifier
R-HSA-5696220
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arsenic is a groundwater contaminant and methylation is an important reaction in its biotransformation. The arsenite(3-) salt form can be methylated by arsenite methyltransferase (AS3MT), transfering a methyl group from the high energy donor S-adenosyl-L-methionine (AdoMet) (Wood et al. 2006). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate).

Literature References
PubMed ID Title Journal Year
16407288 Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies

Wood, TC, Salavagionne, OE, Mukherjee, B, Wang, L, Klumpp, AF, Thomae, BA, Eckloff, BW, Schaid, DJ, Wieben, ED, Weinshilboum, RM

J. Biol. Chem. 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arsenite methyltransferase activity of AS3MT [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created