GSTO1 dimer reduces methylarsonate to methylarsonite

Stable Identifier
R-HSA-5696230
Type
Reaction
Species
Homo sapiens
Compartment
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Glutathione S-transferase omega-1 (GSTO1 aka monomethylarsonic acid reductase, MMA(V) reductase) is a bifunctional enzyme that has glutathione S-transferase activity and also takes part in the biotransformation of inorganic arsenic. It mediates the reduction of methylarsonate to methylarsonite (Zakharyan et al. 2001).

Literature References
PubMed ID Title Journal Year
11511179 Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily

Zakharyan, RA, Sampayo-Reyes, A, Healy, SM, Tsaprailis, G, Board, PG, Liebler, DC, Aposhian, HV

Chem. Res. Toxicol. 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
methylarsonate reductase activity of GSTO1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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