Reactome | OSCAR binds collagen and SP-D

OSCAR binds collagen and SP-D

Stable Identifier

R-HSA-5696356

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Osteoclast-associated receptor (OSCAR) is specifically expressed by preosteoclasts and it signals through the ITAM-harboring adaptor protein Fc receptor gamma (FCRG) (Merck et al. 2004). Collagen types (Col)I, II, and III have been described as OSCAR ligands, and this interaction induce costimulatory signaling in receptor activator for NF-kB-dependent osteoclastogenesis (Barrow et al. 2011, Schultz et al. 2015).
Surfactant protein D (SP-D) is a member of the collagenous lectins (collectins), which provide a first line of humoral innate immune defense to pathogens at mucosal surfaces. SP-D is mainly produced by alveolar type II epithelial cells, but is also produced outside of the lung, in the gastrointestinal and genital mucosae, salivary glands, prostate, kidney, pancreas, skin, and endothelial cells (Madsen et al. 2000). Polymorphisms in the SP-D-encoding gene SFTPD have been associated with chronic obstructive pulmonary disease and ulcerative colitis. OSCAR binds with SP-D and is localized in an intracellular compartment of alveolar macrophages.This interaction may trigger TNF-alpha productiion by inflammatory monocytes (Barrow et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25716998	OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes Palarasah, Y, Byers, DE, Vermi, W, Holehouse, AS, Barrow, AD, Colonna, M, Crouch, E, Holtzman, MJ, Bugatti, M, Skjødt, K	J. Immunol.	2015
15155468	OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells Montero-Julian, F, Lebecque, S, Durand, I, Bates, EE, Merck, E, Trinchieri, G, Gorman, DM, Zurawski, SM, Carra, G, Gaillard, C, Menetrier-Caux, C	Blood	2004
21841309	OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice Raynal, N, Negishi-Koga, T, Takayanagi, H, Pugh, N, Farndale, RW, Lorenzo, J, Delaisse, JM, Bihan, D, Andersen, TL, Rho, J, Choi, Y, Slatter, DA, Cella, M, Barrow, AD, Colonna, M, Kim, T, Trowsdale, J	J. Clin. Invest.	2011