LAIR2 binds collagen

Stable Identifier
R-HSA-5696357
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2 or CD306) a soluble homolog of LAIR1 protein, also has high affinity for various collagen molecules and this can interfere with collagen-dependent platelet aggregation and adhesion. LAIR-2 may function as a natural competitor for LAIR-1, thereby regulating its inhibitory potential (Lebbink et al. 2008, Lenting et al. 2010).

Literature References
PubMed ID Title Journal Year
20730098 Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member

Lenting, PJ, Westerlaken, GH, Denis, CV, Akkerman, JW, Meyaard, L

PLoS ONE 2010
18209062 The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction

Lebbink, RJ, van den Berg, MC, de Ruiter, T, Raynal, N, van Roon, JA, Lenting, PJ, Jin, B, Meyaard, L

J. Immunol. 2008
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