TREM,CD300 binds lipids

Stable Identifier
R-HSA-5696358
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a broad and diverse array of immune cell processes via their paired activating and inhibitory receptor functions (Clark et al. 2000, 2001, 2009a,b). Human CD300 family include 7 members and they have a single Ig-V like domain. Only CD300a and CD300f have long cytoplasmic tails with ITIMs (immunoreceptor tyrosine-based inhibitory motif), whereas the rest of the members have a short cytoplasmic tail and a short transmembrane residue and associate with adaptor proteins such as DDNAX associated protein (DAP)12, DAP10, and the Fc receptor gamma (FCRG) (Clark et al 2009a, Borrego 2013). CD300 receptors bind to polar lipids including extracellular ceramide, phosphatidylserine, and phosphatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activated cells. The CD300 gene complex has been linked to PSOR2, a susceptibility locus for psoriasis (Speckman et al. 2003, Tomfohrde et al. 1994).

Literature References
PubMed ID Title Journal Year
19359216 The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions

Clark, GJ, Ju, X, Tate, C, Hart, DN

Trends Immunol. 2009
10746781 The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17

Clark, GJ, Green, BJ, Hart, DN

Tissue Antigens 2000
19592130 The CD300 molecules regulate monocyte and dendritic cell functions

Clark, GJ, Ju, X, Azlan, M, Tate, C, Ding, Y, Hart, DN

Immunobiology 2009
12483297 Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility

Speckman, RA, Wright Daw, JA, Helms, C, Duan, S, Cao, L, Taillon-Miller, P, Kwok, PY, Menter, A, Bowcock, AM

Hum. Genet. 2003
19149696 Triggering Receptor Expressed on Myeloid Cells (TREM) family and the application of its antagonists

Molloy, EJ

Recent Pat Antiinfect Drug Discov 2009
11556966 The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family

Clark, GJ, Cooper, B, Fitzpatrick, S, Green, BJ, Hart, DN

Tissue Antigens 2001
8178173 Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

Tomfohrde, J, Silverman, A, Barnes, R, Fernandez-Vina, MA, Young, M, Lory, D, Morris, L, Wuepper, KD, Stastny, P, Menter, A

Science 1994
21800138 Specific lipid recognition is a general feature of CD300 and TREM molecules

Cannon, JP, O'Driscoll, M, Litman, GW

Immunogenetics 2012
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