Gap-filling DNA repair synthesis and ligation in GG-NER

Stable Identifier
R-HSA-5696397
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

Global genome nucleotide excision repair (GG-NER) is completed by DNA repair synthesis that fills the single stranded gap created after dual incision of the damaged DNA strand and excision of the ~27-30 bases long oligonucleotide that contains the lesion. DNA synthesis is performed by DNA polymerases epsilon or delta, or the Y family DNA polymerase kappa (POLK), which are loaded to the repair site after 5' incision (Staresincic et al. 2009, Ogi et al. 2010). DNA ligases LIG1 or LIG3 (as part of the LIG3:XRCC1 complex) ligate the newly synthesized stretch of oligonucleotides to the incised DNA strand (Moser et al. 2007).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR

Mol. Cell 2010
17643379 Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

Moser, J, Kool, H, Giakzidis, I, Caldecott, K, Mullenders, LH, Fousteri, M

Mol. Cell 2007
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
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