Reactome: A Curated Pathway Database

Dual Incision in GG-NER

Stable Identifier
R-HSA-5696400
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Double incision at the damaged DNA strand excises the oligonucleotide that contains the lesion from the open bubble. The excised oligonucleotide is ~27-30 bases long. Incision 5' to the damage site, by ERCC1:ERCC4 endonuclease, precedes the incision 3' to the damage site by ERCC5 endonuclease (Staresincic et al. 2009).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database