Reactome | CNTF [extracellular region]

CNTF [extracellular region]

Stable Identifier

R-HSA-5696441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Ciliary neurotrophic factor, CNTF_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15323 KRT31

Expand all

External Reference Information

External Reference

UniProt:P26441 CNTF

Gene Names

CNTF

Chain

chain:1-200

Reference Genes

BioGPS Gene:1270 CNTF

COSMIC (genes):CNTF CNTF

CTD Gene:1270 CNTF

dbSNP Gene:1270 CNTF

ENSEMBL:ENSG00000242689 CNTF

HGNC:2169 CNTF

KEGG Gene (Homo sapiens):1270 CNTF

Monarch:1270 CNTF

NCBI Gene:1270 CNTF

OMIM:118945 CNTF

UCSC:P26441 CNTF

Reference Transcript

RefSeq:NM_000614.3 CNTF

Other Identifiers

0006380072

11734208_s_at

11734209_at

1270

208597_at

3331778

3331779

3331781

3331782

3331783

34590_at

A_14_P112615

A_23_P36100

A_33_P3256778

GE79907

GE88800

GO:0003674

GO:0005125

GO:0005127

GO:0005138

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006464

GO:0006950

GO:0007165

GO:0007275

GO:0007399

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0010628

GO:0019221

GO:0030154

GO:0030424

GO:0042531

GO:0043524

GO:0044877

GO:0046533

GO:0046668

GO:0048143

GO:0048644

GO:0048666

GO:0048680

GO:0048856

GO:0070120

ILMN_1773113

X55889_at

g4758019_3p_at

Participant Of

input

CNTF binds CNTFR complex

hasComponent

CNTF:CNTFR [plasma membrane]

Inferred To

m17 [extracellular region] (Danio rerio)

CNTF [extracellular region] (Bos taurus)

CNTF [extracellular region] (Gallus gallus)

Cntf [extracellular region] (Mus musculus)

Cntf [extracellular region] (Rattus norvegicus)

ZFP91 [extracellular region] (Canis familiaris)

Cross References

RefSeq

NP_000605.1

OpenTargets

ENSG00000242689

GeneCards

P26441

HPA

ENSG00000242689-CNTF

Ensembl

ENST00000361987, ENSG00000242689, ENSP00000355370

PRO

P26441

PDB

1CNT

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42702 LIFR	1	LIFR [plasma membrane] (R-HSA-5693181)	0.747	9
UniProt:P26992 CNTFR	1	CNTFR [plasma membrane] (R-HSA-5696438)	0.747	13
UniProt:P40189 IL6ST	2	IL6ST [plasma membrane] (R-HSA-448453) p-Y-IL6ST [plasma membrane] (R-HSA-8950439)	0.691	10
UniProt:Q99523 SORT1	2	SORT1 [Golgi membrane] (R-HSA-434332) SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221)	0.571	6
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:O14561 NDUFAB1	3	PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q8NG50 RDM1			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q96MA6 AK8	1	AK8 [cytosol] (R-HSA-6788788)	0.556	3
UniProt:P02649 APOE	9	APOE [endosome lumen] (R-HSA-174804) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3

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