BDH2 dehydrogenates 3HBA

Stable Identifier
R-HSA-5696457
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ketone bodies (KBs) are an energy source utilised by mammals, the terminal oxidation of which (termed ketogenesis) is most active during fasting states or starvation. This process normally occurs in the mitochondria of cells. Cytoplasmic de novo lipogenesis and cholesterol synthesis are nonoxidative metabolic fates of ketone bodies. 3-hydroxybutyrate dehydrogenase type 2 (BDH2 aka DHRS6) is a cytosolic, tetrameric enzyme that may have a (as yet undetermined) physiological role in ketone body metabolism, either for energy supply or to generate precursors for lipid and sterol synthesis. The KB substrate (R)-3-hydroxybutyrate (3HBA) is dehydrogenated into acetoacetate (ACA) which can be further metabolised to acetyl-CoA (Guo et al. 2006).

Literature References
PubMed ID Title Journal Year
16380372 Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

Guo, K, Lukacik, P, Papagrigoriou, E, Meier, M, Lee, WH, Adamski, J, Oppermann, U

J. Biol. Chem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-hydroxybutyrate dehydrogenase activity of BDH2 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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Reviewed
Created