USP45 deubiquitinates ERCC1

Stable Identifier
R-HSA-5696465
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP45 ubiquitin protease, mutated in prostate cancer and B-cell lymphoma, deubiquitinates ERCC1. While the mechanism and timing of ERCC1 ubiquitination are not known, deubiquitination of ERCC1 by USP45 enables ERCC1 recruitment to DNA damage sites in nucleotide excision repair (NER) and repair of interstrand cross-links (ICLR) (Perez-Oliva et al. 2015).

Literature References
PubMed ID Title Journal Year
25538220 USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Pérez-Oliva, AB, Lachaud, C, Szyniarowski, P, Muñoz, I, Macartney, T, Hickson, I, Rouse, J, Alessi, DR

EMBO J. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP45 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created