CTF1 binds LIFR:JAKs

Stable Identifier
R-HSA-5696482
Type
Reaction
Species
Homo sapiens
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Cardiotrophin-1 (CTF1/CT-1) is a member of the IL-6 family of cytokines which was originally discovered as a factor which can induce hypertrophy of cardiac myocytes both in vitro and in vivo (Pennica et al. 1995a). Subsequently, CTF1 has been shown to have a wide variety of different effects on cardiac and non cardiac cells including the ability to stimulate the survival of both cardiac and neuronal cells (Latchman 1999). Leukemia inhibitory factor (LIF), CTF1, and oncostatin M (OSM) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp130 and LIF receptor (LIFR) (Pennica et al. 1995b).

Literature References
PubMed ID Title Journal Year
11834704 Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor

Tsuruda, T, Jougasaki, M, Boerrigter, G, Huntley, BK, Chen, HH, D'Assoro, AB, Lee, SC, Larsen, AM, Cataliotti, A, Burnett, JC

Circ. Res. 2002
7862649 Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

Pennica, D, King, KL, Shaw, KJ, Luis, E, Rullamas, J, Luoh, SM, Darbonne, WC, Knutzon, DS, Yen, R, Chien, KR

Proc. Natl. Acad. Sci. U.S.A. 1995
7738033 Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

Pennica, D, Shaw, KJ, Swanson, TA, Moore, MW, Shelton, DL, Zioncheck, KA, Rosenthal, A, Taga, T, Paoni, NF, Wood, WI

J. Biol. Chem. 1995
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