Reactome | CNTF binds CNTFR complex

CNTF binds CNTFR complex

Stable Identifier

R-HSA-5696491

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Ciliary neurotrophic factor (CNTF) is a cytokine a member of the interleukin-6 (IL6) family, expressed in glial cells within the central and peripheral nervous systems. It stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. CNTF is not essential for neural development, but instead acts in response to injury or other stresses. CNTF transduces signal by binding to its receptor complex. This receptor complex consists of a ligand-binding component, CNTF receptor (CNTFR), associated with two signaling receptor components, gp130 and leukemia inhibitory factor receptor (LIFR). The three CNTF receptor components are initially unassociated on the cell surface, and are brought together in step-wise fashion upon CNTF binding. CNTF first binds to CNTFR alpha, then recruits gp130, and finally complexes with LIFR beta (Sleeman et al. 2000, Stahl & Yancopoulos 1994, Robledo et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8627290	Binding interactions of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors Chevalier, S, Pouplard, A, Auguste, P, Praloran, V, Gascan, H, Robledo, O, Coupey, L	J. Neurochem.	1996
10812968	The ciliary neurotrophic factor and its receptor, CNTFR alpha Sleeman, MW, Wiegand, SJ, Anderson, KD, Yancopoulos, GD, Lambert, PD	Pharm Acta Helv	2000