USP12, USP26 deubiquitinate AR

Stable Identifier
R-HSA-5696605
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP12 (as part of a complex with WDR48 and WDR20) and USP26 can bind the androgen receptor and promote its deubiquitination (Faus et al. 2005, Burska et al. 2013, Dirac & Bernards 2010). USP26 is specifically expressed in testis tissue and is a potential infertility gene (Stouffs et al. 2005).

Literature References
PubMed ID Title Journal Year
24056413 Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor

Burska, UL, Harle, VJ, Coffey, K, Darby, S, Ramsey, H, O'Neill, D, Logan, IR, Gaughan, L, Robson, CN

J. Biol. Chem. 2013
20501646 The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling

Dirac, AM, Bernards, R

Mol. Cancer Res. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!