Reactome | CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

Stable Identifier

R-HSA-5696627

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
12917689	CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members Trompouki, E, Hatzivassiliou, E, Tsichritzis, T, Farmer, H, Ashworth, A, Mosialos, G	Nature	2003
12917691	The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination Kovalenko, A, Chable-Bessia, C, Cantarella, G, Israel, A, Wallach, D, Courtois, G	Nature	2003
17981138	Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD Wright, A, Reiley, WW, Chang, M, Jin, W, Lee, AJ, Zhang, M, Sun, SC	Dev. Cell	2007