CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

Stable Identifier
R-HSA-5696627
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).

Literature References
PubMed ID Title Journal Year
12917689 CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

Trompouki, E, Hatzivassiliou, E, Tsichritzis, T, Farmer, H, Ashworth, A, Mosialos, G

Nature 2003
12917691 The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

Kovalenko, A, Chable-Bessia, C, Cantarella, G, Israel, A, Wallach, D, Courtois, G

Nature 2003
17981138 Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD

Wright, A, Reiley, WW, Chang, M, Jin, W, Lee, AJ, Zhang, M, Sun, SC

Dev. Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed