CHD1L is recruited to GG-NER site

Stable Identifier
R-HSA-5696670
Type
Reaction [binding]
Species
Homo sapiens
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A chromatin remodeling enzyme CHD1L (ALC1) is recruited to DNA damage sites through interaction with PARylated PARP1 (or possibly PARP2) (Ahel et al. 2009) or PARylated DDB2 (Pines et al. 2012). CHD1L catalyzes PARP-stimulated nucleosome sliding and is needed for efficient PARP-dependent DNA repair (Ahel et al. 2009). CHD1L depletion or PARP inhibition impair global genomic nucleotide excision repair (GG-NER) of UV-induced DNA damage (Pines et al. 2012).

Literature References
PubMed ID Title Journal Year
19661379 Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

Ahel, D, Horejsí, Z, Wiechens, N, Polo, SE, Garcia-Wilson, E, Ahel, I, Flynn, H, Skehel, M, West, SC, Jackson, SP, Owen-Hughes, T, Boulton, SJ

Science 2009
23045548 PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

Pines, A, Vrouwe, MG, Marteijn, JA, Typas, D, Luijsterburg, MS, Cansoy, M, Hensbergen, P, Deelder, A, de Groot, A, Matsumoto, S, Sugasawa, K, Thoma, N, Vermeulen, W, Vrieling, H, Mullenders, L

J. Cell Biol. 2012
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