Reactome | DDX1 [nucleoplasm]

DDX1 [nucleoplasm]

Stable Identifier

R-HSA-5696771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ATP-dependent RNA helicase DDX1 ecNumber3.6.4.13/ecNumber, DDX1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92499 DDX1

Gene Names

DDX1

Chain

chain:1-740

Reference Genes

BioGPS Gene:1653 DDX1

COSMIC (genes):DDX1 DDX1

CTD Gene:1653 DDX1

dbSNP Gene:1653 DDX1

ENSEMBL:ENSG00000079785 DDX1

HGNC:2734 DDX1

KEGG:hsa:1653 DDX1

Monarch:1653 DDX1

NCBI Gene:1653 DDX1

OMIM:601257 DDX1

UCSC:Q92499 DDX1

Reference Transcript

RefSeq:NM_004939.2 DDX1

Participates

as a component of

tRNA ligase complex [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENST00000233084, ENSP00000233084, ENSP00000370745, ENST00000434671, ENSG00000079785, ENSP00000504080, ENST00000677302, ENST00000381341, ENSP00000413767

OpenTargets

ENSG00000079785

IntEnz

3.6.4.13

GeneCards

DDX1

HPA

ENSG00000079785-DDX1

PRO

Q92499

Pharos - Targets

Q92499

GlyGen

Q92499

HMDB Protein

HMDBP11663

PDB

4XW3, 8TBX

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.602	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	11
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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