Reactome: A Curated Pathway Database

TSEN complex cleaves the intron from pre-tRNA

Stable Identifier
R-HSA-5696813
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The TSEN complex endonucleolytically cleaves 5' and 3' of introns in tRNAs, leaving a 2',3' cyclic phosphate on the 5' exon and a 5' hydroxyl on the 3' exon (Paushkin et al. 2004, Trotta et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
tRNA-specific ribonuclease activity of TSEN complex [nucleoplasm] TSEN complex [nucleoplasm] tRNA-specific ribonuclease activity (0004549)