Reactome: A Curated Pathway Database

ELAC2 cleaves the 3' end of pre-tRNA

Stable Identifier
R-HSA-5696815
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ELAC2, a RNaseZ activity in humans, endonucleolytically cleaves pre-tRNAs near the 3' end, generating a 3' hydroxyl group to which the nucleotides CCA will be polymerized (Takaku et al. 2004, Yan et al. 2006, Elbarbary et al. 2008). ELAC2 is located in both the nucleus and mitochondria (Brzezniak et al. 2011). ELAC1, a homologue of ELAC2, is located in the cytosol (Rossmanith 2011) and cleaves 3' ends of tRNAs in vitro (Takaku et al. 2003).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
tRNA-specific ribonuclease activity of ELAC2 [nucleoplasm] ELAC2 [nucleoplasm] tRNA-specific ribonuclease activity (0004549)