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MTHFD1L ligates HCOOH to THF to form 10-formyl-THF

Stable Identifier
R-HSA-5696839
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

All C1-tetrahydrofolate (C1-THF) synthases characterised to date are trifunctional, containing the activities of 5,10-methylene-THF dehydrogenase, 5,10-methenyl-THF cyclohydrolase, and 10-formyl-THF synthetase. Mitochondrial monofunctional C1-tetrahydrofolate synthase (MTHFD1L) only possesses 10-formyl-THF synthetase activity and it reversibly ligates formate (HCOOH) to tetrahydrofolate (THF), forming 10-formyltetrahydrofolate (10-formyl-THF) (Prasannan et al. 2003, Walkup & Appling 2005). MTHFD1L is functional as a homodimer and could be a missing reaction in one-carbon folate metabolism linking the metabolism of formate from the cytosol to mitochondria (Pike et al. 2010).

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Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events