Reactome | IDE [mitochondrial outer membrane]

IDE [mitochondrial outer membrane]

Stable Identifier

R-HSA-5696861

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
        
        USP30:MOM proteins [mitochondrial outer membrane] (Homo sapiens)
        
        MOM proteins [mitochondrial outer membrane] (Homo sapiens)
        
        IDE [mitochondrial outer membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

BioGPS Gene:3416 IDE

COSMIC (genes):IDE IDE

CTD Gene:3416 IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

HGNC:5381 IDE

KEGG:hsa:3416 IDE

Monarch:3416 IDE

NCBI Gene:3416 IDE

OMIM:146680 IDE

UCSC:P14735 IDE

Reference Transcript

Participates

as a candidate of

MOM proteins [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

IDE [endosome lumen]

IDE [cytosol]

IDE [peroxisomal matrix]

PolyUb-IDE [mitochondrial outer membrane]

Inferred To

STE23 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

mug138 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

ide [mitochondrial outer membrane] (Danio rerio)

IDE [mitochondrial outer membrane] (Bos taurus)

IDE [mitochondrial outer membrane] (Canis familiaris)

IDE [mitochondrial outer membrane] (Gallus gallus)

IDE [mitochondrial outer membrane] (Sus scrofa)

Ide [mitochondrial outer membrane] (Drosophila melanogaster)

Ide [mitochondrial outer membrane] (Mus musculus)

Ide [mitochondrial outer membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004960.2, NP_001159418.1

Guide to Pharmacology - Targets

2371

OpenTargets

ENSG00000119912

ENSEMBL

ENSP00000265986, ENSG00000119912, ENST00000371581, ENST00000265986, ENSP00000360637

ZINC - Substances

IDE_HUMAN

ZINC target

P14735

PRO

P14735

GlyGen

P14735

PDB

4M1C, 7RZH, 7RZI, 4GS8, 7RZE, 4NXO, 3OFI, 6EDS, 5CJO, 2WK3, 4IFH, 2G49, 3QZ2, 6BFC, 6BF8, 4PES, 4PF7, 6BF7, 3CWW, 6BF9, 2JG4, 7K1F, 4PF9, 3H44, 2JBU, 2G54, 7K1D, 4IOF, 5WOB, 6MQ3, 3E4Z, 4LTE, 7RZF, 4DTT, 5UOE, 6BYZ, 2G48, 2G47, 2WC0, 7RZG, 4DWK, 6B3Q, 3N57, 2WBY, 3N56, 4QIA, 6BF6, 4RAL, 3E4A, 7K1E, 4GSC, 3E50, 6B70, 6B7Z, 6B7Y, 4PFC, 3HGZ, 2G56, 2YPU, 4GSF, 4RE9

HPA

ENSG00000119912-IDE

GeneCards

IDE

Pharos - Targets

P14735

ZINC - Predictions - Purchasable

IDE_HUMAN

HMDB Protein

HMDBP10019

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.643	3
UniProt:P10147 CCL3	2	CCL3(27-92) [extracellular region] (R-HSA-6785011) CCL3(24-92) [extracellular region] (R-HSA-443989)	0.618	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P08670 VIM	12	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) p39-VIM [cytosol] (R-HSA-9948102)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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