Reactome | USP25 [cytosol]

USP25 [cytosol]

Stable Identifier

R-HSA-5696900

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 25 ecNumber3.4.19.12/ecNumber, UBP25_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UHP3 USP25

Gene Names

USP25, USP21

Chain

chain:1-1055

Reference Genes

BioGPS Gene:29761 USP25

COSMIC (genes):USP25 USP25

CTD Gene:29761 USP25

dbSNP Gene:29761 USP25

ENSEMBL:ENSG00000155313 USP25

ENSEMBL_homo_sapiens_GENE:ENSG00000155313.16 USP25

HGNC:12624 USP25

KEGG Gene (Homo sapiens):29761 USP25

Monarch:29761 USP25

NCBI Gene:29761 USP25

OMIM:604736 USP25

UCSC:Q9UHP3 USP25

Reference Transcript

Other Identifiers

11745425_a_at

11753044_a_at

11755051_a_at

1555559_PM_s_at

1555559_s_at

16921591

220419_PM_s_at

220419_s_at

223167_PM_s_at

223167_s_at

29761

3915086

3915088

3915089

3915090

3915091

3915098

3915099

3915101

3915105

3915107

3915109

3915112

3915115

3915116

3915118

3915119

3915122

3915123

3915124

3915125

3915126

3915128

3915129

3915132

3915133

3915134

3915136

3915137

3915139

3915142

3915145

3915146

3915147

3915148

3915149

45864_r_at

54822_at

8067903

91419_at

A_14_P120222

A_23_P256676

A_24_P139208

GE61933

GO:0003824

GO:0004843

GO:0005515

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0006508

GO:0008233

GO:0008234

GO:0016579

GO:0016787

GO:0019783

GO:0030163

GO:0031625

GO:0031647

GO:0032183

GO:0036211

GO:0043130

GO:0043226

GO:0051117

GO:0070536

GO:0071108

GO:0140096

GO:1904293

HMNXSV003009051

HMNXSV003036118

ILMN_1670764

PH_hs_0010944

TC21000039.hg

g6941887_3p_a_at

g7019564_3p_a_at

Participates

as a component of

as a member of

USP4,USP25 [cytosol] (Homo sapiens)

Inferred To

UBP15 [cytosol] (Saccharomyces cerevisiae)

USP25 [cytosol] (Bos taurus)

USP25 [cytosol] (Caenorhabditis elegans)

USP25 [cytosol] (Sus scrofa)

Homologues of USP25 [cytosol] (Saccharomyces cerevisiae)

Usp25 [cytosol] (Mus musculus)

Usp25 [cytosol] (Rattus norvegicus)

usp25 [cytosol] (Xenopus tropicalis)

UBP2 [cytosol] (Saccharomyces cerevisiae)

usp7 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001269970.1, NP_037528.3, NP_001269971.1

OpenTargets

ENSG00000155313

GeneCards

Q9UHP3

HPA

ENSG00000155313-USP25

Ensembl

ENSP00000285681, ENST00000285681, ENSP00000285679, ENST00000285679, ENSP00000383044, ENSG00000155313, ENST00000400183

PRO

Q9UHP3

Pharos - Targets

Q9UHP3

HMDB Protein

HMDBP11589

PDB

6H4J, 6HEM, 5O71, 6H4K, 5GP7, 6HEL, 2MUX

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.831	8
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.718	6
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3

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