Reactome | USP12 [nucleoplasm]

USP12 [nucleoplasm]

Stable Identifier

R-HSA-5696907

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin carboxyl-terminal hydrolase 12, UBP12_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP12, USP26 deubiquitinate AR (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        USP12 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        USP12 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        USP12 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75317 USP12

Gene Names

USP12, UBH1, USP12L1

Chain

chain:1-370

Reference Genes

BioGPS Gene:219333 USP12

COSMIC (genes):USP12 USP12

CTD Gene:219333 USP12

dbSNP Gene:219333 USP12

ENSEMBL:ENSG00000152484 USP12

ENSEMBL_homo_sapiens_GENE:ENSG00000152484.14 USP12

HGNC:20485 USP12

KEGG Gene (Homo sapiens):219333 USP12

Monarch:219333 USP12

NCBI Gene:219333 USP12

OMIM:603091 USP12

UCSC:O75317 USP12

Reference Transcript

RefSeq:NM_182488.3 USP12

Other Identifiers

11733100_at

11733101_at

11759092_at

16777602

213327_PM_s_at

213327_s_at

215886_3p_x_at

215886_PM_x_at

215886_x_at

219333

2840540

2840543

2840545

34803_at

3506745

3506746

3506747

3506748

3506749

3506750

3506752

3506755

3506759

3506760

3506764

3506765

3506770

3506772

3506787

3506788

3506789

3983470

3983471

3983474

3983476

3983478

3983480

3983482

4028659

4028660

4028661

4028664

4028665

7970696

8180323

A_23_P217596

A_24_P237613

GE80167

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0008233

GO:0008234

GO:0016020

GO:0016579

GO:0016787

GO:0036211

GO:0043226

GO:0046872

GO:0101005

GO:0140096

HMNXSV003005204

Hs.42400.0.S1_3p_a_at

Hs.42400.2.S1_3p_a_at

Hs.42400.2.S1_3p_s_at

ILMN_1687284

PH_hs_0028872

TC13000506.hg

Participates

as a component of

USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)

Inferred To

usp12 [nucleoplasm] (Dictyostelium discoideum)

usp12 [nucleoplasm] (Xenopus tropicalis)

USP12 [nucleoplasm] (Bos taurus)

USP12 [nucleoplasm] (Canis familiaris)

USP12 [nucleoplasm] (Gallus gallus)

USP12 [nucleoplasm] (Mus musculus)

USP12 [nucleoplasm] (Sus scrofa)

ubp9 [nucleoplasm] (Schizosaccharomyces pombe)

Usp12 [nucleoplasm] (Rattus norvegicus)

Usp12-46 [nucleoplasm] (Drosophila melanogaster)

usp-46 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_872294.2

OpenTargets

ENSG00000152484

GeneCards

O75317

HPA

ENSG00000152484-USP12

Ensembl

ENST00000282344, ENSG00000152484, ENSP00000282344

PRO

O75317

Pharos - Targets

O75317

PDB

5K16, 5K1B, 5L8W, 5K1A, 5K1C

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAF3 WDR48	3	p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673645) WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673617) WDR48 [nucleoplasm] (R-HSA-419549)	0.564	3
UniProt:P36957 DLST	4	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3