USP28 deubiquitinates CLSPN and MYC

Stable Identifier
R-HSA-5696914
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP28 is Involved in DNA damage induced apoptosis by specifically stabilizing and deubiquitinating proteins of the DNA damage pathway including CLSPN (Zhang et al. 2006). It also binds to the nucleoplasmic alpha isoform of Fbw7, counteracting FBW7 ubiquitin ligase activity by deubiquitinating MYC in the nucleoplasm, which reduces MYC proteasomal degradation (Popov et al. 2007).

Literature References
PubMed ID Title Journal Year
17873522 Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

Popov, N, Herold, S, Llamazares, M, Schülein, C, Eilers, M

Cell Cycle 2007
16901786 A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

Zhang, D, Zaugg, K, Mak, TW, Elledge, SJ

Cell 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP28:PolyUb-CLSPN, PolyUb-MYC [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed