Reactome | FKBP8 [mitochondrial outer membrane]

FKBP8 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5696928

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Peptidyl-prolyl cis-trans isomerase FKBP8, FKBP8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14318 FKBP8

Gene Names

FKBP8, FKBP38

Chain

chain:1-412

Reference Genes

BioGPS Gene:23770 FKBP8

COSMIC (genes):FKBP8 FKBP8

CTD Gene:23770 FKBP8

dbSNP Gene:23770 FKBP8

ENSEMBL:ENSG00000105701 FKBP8

ENSEMBL_homo_sapiens_GENE:ENSG00000105701.16 FKBP8

HGNC:3724 FKBP8

KEGG Gene (Homo sapiens):23770 FKBP8

Monarch:23770 FKBP8

NCBI Gene:23770 FKBP8

OMIM:604840 FKBP8

UCSC:Q14318 FKBP8

Reference Transcript

Other Identifiers

11743133_a_at

11743134_x_at

11746216_x_at

16870432

208255_3p_s_at

208255_PM_s_at

208255_s_at

2375250

2375253

23770

3855072

3855073

3855074

3855075

3855076

3855077

3855078

3855080

3855081

3855082

3855084

3855085

3855086

3855088

3855089

40850_3p_at

40850_PM_at

40850_at

4886183C_3p_s_at

74642_r_at

8035494

A_23_P39336

A_33_P3272990

GE81765

GO:0001708

GO:0001933

GO:0003755

GO:0003824

GO:0005515

GO:0005516

GO:0005739

GO:0005740

GO:0005783

GO:0005789

GO:0005829

GO:0006457

GO:0006914

GO:0006915

GO:0007005

GO:0007224

GO:0009953

GO:0010468

GO:0012501

GO:0012505

GO:0016020

GO:0016853

GO:0021904

GO:0021915

GO:0023052

GO:0030154

GO:0030509

GO:0030510

GO:0030513

GO:0031966

GO:0032991

GO:0035264

GO:0035556

GO:0036211

GO:0042802

GO:0043010

GO:0043066

GO:0043226

GO:0044183

GO:0046872

GO:0048665

GO:0048856

GO:0070585

GO:0097718

GO:0140096

GO:1903146

HMNXSV003005273

ILMN_1733947

L37033_at

PH_hs_0010396

TC19001291.hg

g6912367_3p_s_at

Participates

as a candidate of

MOM proteins [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

PolyUb-FKBP8 [mitochondrial outer membrane]

Inferred To

fkbp8 [mitochondrial outer membrane] (Danio rerio)

FKBP8 [mitochondrial outer membrane] (Bos taurus)

FKBP8 [mitochondrial outer membrane] (Canis familiaris)

FKBP8 [mitochondrial outer membrane] (Gallus gallus)

FKBP8 [mitochondrial outer membrane] (Sus scrofa)

zda [mitochondrial outer membrane] (Drosophila melanogaster)

Fkbp8 [mitochondrial outer membrane] (Mus musculus)

Fkbp8 [mitochondrial outer membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_036313.3, XP_011526165.1, NP_001295302.1

Guide to Pharmacology - Targets

3177

OpenTargets

ENSG00000105701

HPA

ENSG00000105701-FKBP8

GeneCards

Q14318

Ensembl

ENST00000596558, ENSP00000476767, ENST00000597960, ENST00000222308, ENSP00000471700, ENSP00000222308, ENSP00000472302, ENSG00000105701, ENST00000608443

PRO

Q14318

Pharos - Targets

Q14318

HMDB Protein

HMDBP07687

PDB

2MF9, 5MGX, 2AWG, 2F2D, 2D9F, 3EY6

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.683	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.669	8
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.632	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P25025 CXCR2	2	CXCR2 [secretory granule membrane] (R-HSA-6804771) CXCR2 [plasma membrane] (R-HSA-373796)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.547	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	3
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.527	2
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	2
UniProt:P03431 PB1	4	PB1 [extracellular region] (R-FLU-169246) PB1 [endosome lumen] (R-FLU-189137) PB1 [cytosol] (R-FLU-195940) PB1 [nucleoplasm] (R-FLU-188843)	0.499	5

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