USP33 deubiquitinates CCP110,ARRB

Stable Identifier
R-HSA-5696945
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP33 regulates centrosome duplication by mediating deubiquitination and stabilization of CCP110 in S and G2/M phase (Li et al. 2013) and regulates G-protein coupled receptor (GPCR) signaling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) (Shenoy et al. 2009).

Literature References
PubMed ID Title Journal Year
19363159 Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

Shenoy, SK, Modi, AS, Shukla, AK, Xiao, K, Berthouze, M, Ahn, S, Wilkinson, KD, Miller, WE, Lefkowitz, RJ

Proc. Natl. Acad. Sci. U.S.A. 2009
23486064 USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

Li, J, D'Angiolella, V, Seeley, ES, Kim, S, Kobayashi, T, Fu, W, Campos, EI, Pagano, M, Dynlacht, BD

Nature 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP33:PolyUb-CCP110,PolyUb-ARRB1,PolyUb-ARRB2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed