USP47 deubiquitinates POLB

Stable Identifier
R-HSA-5696947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP47 specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), increasing its stability and thereby playing a role in base-excision repair (Parsons et al. 2011).
Literature References
PubMed ID Title Journal Year
21362556 USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

Kessler, BM, Edelmann, MJ, Dianov, GL, Parsons, JL, Khoronenkova, SV, Dianova, II

Mol. Cell 2011
Participants
Participates
Catalyst Activity

cysteine-type deubiquitinase activity of USP47:PolyUb-POLB [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!