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GPS1 [nucleoplasm]
Stable Identifier
R-HSA-5697010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COP9 signalosome complex subunit 1, CSN1_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
GPS1 [nucleoplasm] (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
GPS1 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
GPS1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
GPS1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
GPS1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13098 GPS1
Gene Names
GPS1, COPS1, CSN1
Chain
initiator methionine:, chain:2-491
Reference Genes
BioGPS Gene:2873 GPS1
COSMIC (genes):GPS1 GPS1
CTD Gene:2873 GPS1
dbSNP Gene:2873 GPS1
ENSEMBL:ENSG00000169727 GPS1
ENSEMBL_homo_sapiens_GENE:ENSG00000169727.14 GPS1
HGNC:4549 GPS1
KEGG Gene (Homo sapiens):2873 GPS1
Monarch:2873 GPS1
NCBI Gene:2873 GPS1
OMIM:601934 GPS1
UCSC:Q13098 GPS1
Reference Transcript
RefSeq:NM_001321092.1 GPS1
RefSeq:NM_212492.2 GPS1
RefSeq:NM_004127.5 GPS1
RefSeq:XM_017024534.1 GPS1
Other Identifiers
11715535_a_at
16838988
217782_3p_s_at
217782_PM_s_at
217782_s_at
2873
3738493
3738494
3738495
3738496
3738497
3738498
3738501
3738502
3738503
3738504
3738505
3738507
3738508
3738509
3738511
3738513
3738515
3738517
3738519
3738520
3738521
3738522
3738523
73190_at
78787_at
8010747
A_23_P158662
GO:0000338
GO:0005095
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0007254
GO:0008180
GO:0023052
GO:0032991
GO:0036211
GO:0043226
GO:0045116
GO:0098772
GO:2000434
HMNXSV003008519
ILMN_1769960
ILMN_1795876
PH_hs_0026722
TC17000945.hg
U20285_at
g13435380_3p_a_at
g13435380_3p_at
g13435380_3p_x_at
Participates
as a component of
COP9 signalosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
GPS1 [cytosol]
Inferred To
GPS1 [nucleoplasm]
(Bos taurus)
GPS1 [nucleoplasm]
(Canis familiaris)
GPS1 [nucleoplasm]
(Gallus gallus)
GPS1 [nucleoplasm]
(Sus scrofa)
gps1 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of GPS1 [nucleoplasm]
(Danio rerio)
CSN1b [nucleoplasm]
(Drosophila melanogaster)
csn-1 [nucleoplasm]
(Caenorhabditis elegans)
Gps1 [nucleoplasm]
(Mus musculus)
Gps1 [nucleoplasm]
(Rattus norvegicus)
csn1 [nucleoplasm]
(Dictyostelium discoideum)
csn1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_004118.3
,
NP_001308021.1
,
XP_016880023.1
,
NP_997657.1
OpenTargets
ENSG00000169727
GeneCards
Q13098
HPA
ENSG00000169727-GPS1
Ensembl
ENSG00000169727
,
ENST00000392358
,
ENST00000306823
,
ENST00000578552
,
ENSP00000376167
,
ENSP00000302873
,
ENSP00000462265
PRO
Q13098
Pharos - Targets
Q13098
PDB
6R7I
,
6R6H
,
4D10
,
6R7F
,
8H3F
,
6R7N
,
4D18
,
4WSN
,
6R7H
,
8H3A
,
8H38
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.592
6
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
2
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.462
5
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