Reactome | COPS3 [nucleoplasm]

COPS3 [nucleoplasm]

Stable Identifier

R-HSA-5697017

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP9 signalosome complex subunit 3, CSN3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UNS2 COPS3

Gene Names

COPS3, CSN3

Chain

initiator methionine:1, chain:2-423

Reference Genes

BioGPS Gene:8533 COPS3

COSMIC (genes):COPS3 COPS3

CTD Gene:8533 COPS3

dbSNP Gene:8533 COPS3

ENSEMBL:ENSG00000141030 COPS3

HGNC:2239 COPS3

KEGG Gene (Homo sapiens):8533 COPS3

Monarch:8533 COPS3

NCBI Gene:8533 COPS3

OMIM:604665 COPS3

UCSC:Q9UNS2 COPS3

Reference Transcript

Other Identifiers

0005340164

11757601_a_at

16841885

202078_at

35349_at

3747718

3747719

3747720

3747721

3747725

3747727

3747728

3747730

3747734

3747735

3747736

3747740

3747742

3747743

3747744

3747745

3747746

8013094

8533

A_23_P89199

GE54246

GO:0000338

GO:0000715

GO:0001701

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006283

GO:0006464

GO:0006511

GO:0006950

GO:0007165

GO:0008150

GO:0008180

GO:0009056

GO:0009416

GO:0009790

GO:0032991

GO:0034641

GO:0043226

GO:0043687

GO:0048856

GO:0051276

ILMN_1770732

PH_hs_0000611

TC17001186.hg

g4502974_3p_at

Participant Of

hasComponent

COP9 signalosome [nucleoplasm]

Other forms of this molecule

COPS3 [cytosol]

Inferred To

Ghost homologue of COPS3 [nucleoplasm] (Bos taurus)

CSN3 [nucleoplasm] (Drosophila melanogaster)

csn3 [nucleoplasm] (Dictyostelium discoideum)

csn3 [nucleoplasm] (Schizosaccharomyces pombe)

Cops3 [nucleoplasm] (Mus musculus)

Cops3 [nucleoplasm] (Rattus norvegicus)

csn-3 [nucleoplasm] (Caenorhabditis elegans)

COPS3 [nucleoplasm] (Canis familiaris)

COPS3 [nucleoplasm] (Gallus gallus)

COPS3 [nucleoplasm] (Sus scrofa)

cops3 [nucleoplasm] (Danio rerio)

cops3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001303286.1, NP_001303284.1, NP_001303285.1, NP_001303287.1, NP_001303283.1, XP_005256894.1, NP_001186054.1, NP_003644.2

OpenTargets

ENSG00000141030

HPA

ENSG00000141030-COPS3

GeneCards

Q9UNS2

Ensembl

ENST00000539941, ENSG00000141030, ENSP00000268717, ENST00000268717, ENSP00000437606

PRO

Q9UNS2

PDB

4WSN, 6R6H, 6R7H, 6R7F, 6R7N, 4D10, 6R7I, 4D18

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.581	3
UniProt:O43559 FRS3	3	FRS3 [plasma membrane] (R-HSA-191482) p-5Y-FRS3 [plasma membrane] (R-HSA-191475) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q8TBF2 PRXL2B	1	FAM213B [cytosol] (R-HSA-2142703)	0.556	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.508	2
UniProt:Q13616 CUL1	3	CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [cytosol] (R-HSA-174230)	0.462	6

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