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COPS3 [nucleoplasm]
Stable Identifier
R-HSA-5697017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COP9 signalosome complex subunit 3, CSN3_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNS2 COPS3
Gene Names
COPS3, CSN3
Chain
initiator methionine:1, chain:2-423
Reference Genes
BioGPS Gene:8533 COPS3
COSMIC (genes):COPS3 COPS3
CTD Gene:8533 COPS3
dbSNP Gene:8533 COPS3
ENSEMBL:ENSG00000141030 COPS3
HGNC:2239 COPS3
KEGG Gene (Homo sapiens):8533 COPS3
Monarch:8533 COPS3
NCBI Gene:8533 COPS3
OMIM:604665 COPS3
UCSC:Q9UNS2 COPS3
Reference Transcript
RefSeq:NM_001316354.1 COPS3
RefSeq:NM_003653.3 COPS3
RefSeq:NM_001316356.1 COPS3
RefSeq:NM_001316357.1 COPS3
RefSeq:NM_001199125.1 COPS3
RefSeq:NM_001316355.1 COPS3
RefSeq:NM_001316358.1 COPS3
RefSeq:XM_005256837.4 COPS3
Other Identifiers
0005340164
11757601_a_at
16841885
202078_at
35349_at
3747718
3747719
3747720
3747721
3747725
3747727
3747728
3747730
3747734
3747735
3747736
3747740
3747742
3747743
3747744
3747745
3747746
8013094
8533
A_23_P89199
GE54246
GO:0000338
GO:0000715
GO:0001701
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006283
GO:0006464
GO:0006511
GO:0006950
GO:0007165
GO:0008150
GO:0008180
GO:0009056
GO:0009416
GO:0009790
GO:0032991
GO:0034641
GO:0043226
GO:0043687
GO:0048856
GO:0051276
HMNXSV003018891
HMNXSV003031923
ILMN_1770732
PH_hs_0000611
TC17001186.hg
g4502974_3p_at
Participates
as a component of
COP9 signalosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
COPS3 [cytosol]
Inferred To
Ghost homologue of COPS3 [nucleoplasm]
(Bos taurus)
CSN3 [nucleoplasm]
(Drosophila melanogaster)
csn3 [nucleoplasm]
(Dictyostelium discoideum)
csn3 [nucleoplasm]
(Schizosaccharomyces pombe)
Cops3 [nucleoplasm]
(Mus musculus)
Cops3 [nucleoplasm]
(Rattus norvegicus)
csn-3 [nucleoplasm]
(Caenorhabditis elegans)
COPS3 [nucleoplasm]
(Canis familiaris)
COPS3 [nucleoplasm]
(Gallus gallus)
COPS3 [nucleoplasm]
(Sus scrofa)
cops3 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001303284.1
,
NP_001303286.1
,
NP_001303283.1
,
XP_005256894.1
,
NP_003644.2
,
NP_001303285.1
,
NP_001303287.1
,
NP_001186054.1
OpenTargets
ENSG00000141030
HPA
ENSG00000141030-COPS3
GeneCards
Q9UNS2
Ensembl
ENST00000268717
,
ENSP00000437606
,
ENST00000539941
,
ENSG00000141030
,
ENSP00000268717
PRO
Q9UNS2
PDB
4D18
,
6R7I
,
6R6H
,
6R7F
,
6R7H
,
4WSN
,
6R7N
,
4D10
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14832 PHYH
4
PHYH(1-338) [cytosol]
(R-HSA-9033143)
PHYH [peroxisomal matrix]
(R-HSA-389574)
PHYH(1-338) [peroxisomal matrix]
(R-HSA-9033535)
PHYH(1-30) [peroxisomal matrix]
(R-HSA-9033518)
0.675
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.581
3
UniProt:P02545-2 LMNA
5
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q8TBF2 PRXL2B
1
FAM213B [cytosol]
(R-HSA-2142703)
0.556
5
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
3
UniProt:O43559 FRS3
3
FRS3 [plasma membrane]
(R-HSA-191482)
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:P29474 NOS3
7
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
NOS3 [cytosol]
(R-HSA-202114)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
0.556
3
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P51149 RAB7A
7
GGC-RAB7A [cytosol]
(R-HSA-8870438)
GGC-RAB7A [lysosomal membrane]
(R-HSA-8877454)
RAB7A [lysosomal membrane]
(R-HSA-2213231)
RAB7A [phagocytic vesicle membrane]
(R-HSA-9636586)
RAB7A [cytosol]
(R-HSA-8870415)
RAB7A [plasma membrane]
(R-HSA-6804990)
RAB7A [secretory granule membrane]
(R-HSA-6804969)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.508
2
UniProt:Q13616 CUL1
3
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [cytosol]
(R-HSA-174230)
0.462
6
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