Reactome | COPS5 [nucleoplasm]

COPS5 [nucleoplasm]

Stable Identifier

R-HSA-5697019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP9 signalosome complex subunit 5, CSN5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92905 COPS5

Gene Names

COPS5, CSN5, JAB1

Chain

initiator methionine:, chain:2-334

Reference Genes

BioGPS Gene:10987 COPS5

COSMIC (genes):COPS5 COPS5

CTD Gene:10987 COPS5

dbSNP Gene:10987 COPS5

ENSEMBL:ENSG00000121022 COPS5

HGNC:2240 COPS5

KEGG:hsa:10987 COPS5

Monarch:10987 COPS5

NCBI Gene:10987 COPS5

OMIM:604850 COPS5

UCSC:Q92905 COPS5

Reference Transcript

RefSeq:NM_006837.2 COPS5

Other Identifiers

10987

11721461_a_at

11754844_x_at

17077888

1789_at

201652_PM_at

201652_at

3138979

3138980

3138981

3138982

3138983

3138984

3138985

3138987

3138990

3138992

3138993

3138994

3138995

3138996

3138997

3138998

3138999

3139000

3139001

3139002

3139003

3139004

3139005

3139006

3139007

3139008

3139009

3139012

3139014

8151136

A_23_P71419

GE62793

GO:0000338

GO:0000785

GO:0003713

GO:0003743

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005852

GO:0006355

GO:0006412

GO:0006413

GO:0006508

GO:0008021

GO:0008180

GO:0008233

GO:0008237

GO:0016192

GO:0016787

GO:0019784

GO:0019899

GO:0031410

GO:0035718

GO:0043066

GO:0043226

GO:0043687

GO:0045116

GO:0045182

GO:0045202

GO:0045944

GO:0046328

GO:0046872

GO:0048471

GO:0051091

GO:0051726

GO:0060090

GO:0140096

GO:0140110

GO:0140492

GO:1903894

GO:1990182

GO:2000434

HMNXSV003027773

ILMN_1736002

PH_hs_0030317

U65928_at

g5803045_3p_at

Participates

as a component of

COP9 signalosome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

COPS5 [cytosol]

Inferred To

COPS5 [nucleoplasm] (Bos taurus)

COPS5 [nucleoplasm] (Caenorhabditis elegans)

COPS5 [nucleoplasm] (Canis familiaris)

COPS5 [nucleoplasm] (Danio rerio)

COPS5 [nucleoplasm] (Dictyostelium discoideum)

COPS5 [nucleoplasm] (Drosophila melanogaster)

COPS5 [nucleoplasm] (Gallus gallus)

COPS5 [nucleoplasm] (Mus musculus)

COPS5 [nucleoplasm] (Schizosaccharomyces pombe)

COPS5 [nucleoplasm] (Sus scrofa)

COPS5 [nucleoplasm] (Xenopus tropicalis)

Cops5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_006828.2

OpenTargets

ENSG00000121022

ENSEMBL

ENSP00000350512, ENST00000357849

HPA

ENSG00000121022-COPS5

PRO

Q92905

Pharos - Targets

Q92905

GlyGen

Q92905

PDB

5M5Q, 5JOG, 6R7H, 4D18, 6R7I, 5JOH, 4D10, 6R6H, 8H38, 4WSN, 8H3A, 8H3F, 4F7O, 6R7F

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.837	10
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.736	9
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.723	14
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.643	4
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.639	10
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.602	3
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.593	3
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.593	4
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	5
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.553	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.547	2
UniProt:Q9NSI6 BRWD1	1	BRWD1 [nucleoplasm] (R-HSA-8863306)	0.547	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.547	2
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.528	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	6
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	3
UniProt:Q15048 LRRC14	1	LRRC14 [cytosol] (R-HSA-9749455)	0.527	3
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.462	2

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