Reactome | CASP3(1-277) [cytosol]

CASP3(1-277) [cytosol]

Stable Identifier

R-HSA-57021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-3 precursor, Apopain precursor , Cysteine protease CPP32, Yama protein, CPP-32, CASP-3, SREBP cleavage activity 1, SCA-1

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
      - Activation of caspase-3 (Homo sapiens)
        
        CASP3(1-277) dimer [cytosol] (Homo sapiens)
        
        CASP3(1-277) [cytosol] (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
        
        Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
        
        CASP3(1-277) dimer [cytosol] (Homo sapiens)
        
        CASP3(1-277) [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
      - NADE modulates death signalling (Homo sapiens)
        
        p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
        
        Procaspases 2, 3 [cytosol] (Homo sapiens)
        
        CASP3(1-277) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42574 CASP3

Gene Names

CASP3, CPP32

Chain

propeptide:1-9, propeptide:10-28, chain:29-175, chain:176-277

Reference Genes

BioGPS Gene:836 CASP3

COSMIC (genes):CASP3 CASP3

CTD Gene:836 CASP3

dbSNP Gene:836 CASP3

ENSEMBL:ENSG00000164305 CASP3

HGNC:1504 CASP3

KEGG:hsa:836 CASP3

Monarch:836 CASP3

NCBI Gene:836 CASP3

OMIM:600636 CASP3

UCSC:P42574 CASP3

Reference Transcript

Other Identifiers

11717805_a_at

11719838_a_at

11719839_a_at

16982011

202763_PM_at

202763_at

236729_PM_at

236729_at

2796488

2796489

2796490

2796491

2796492

2796493

2796494

2796495

2796496

2796497

2796498

2796499

2796500

2796502

2796503

2796504

2796505

2796506

2796507

36143_at

76948_at

8103922

836

A_23_P92410

A_33_P3278118

GE58946

GO:0001554

GO:0001666

GO:0001782

GO:0001818

GO:0002020

GO:0002376

GO:0003824

GO:0004175

GO:0004190

GO:0004197

GO:0004861

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0006974

GO:0007413

GO:0007507

GO:0007605

GO:0007611

GO:0008047

GO:0008233

GO:0008234

GO:0008627

GO:0009410

GO:0009411

GO:0009611

GO:0009749

GO:0010038

GO:0010165

GO:0012501

GO:0014069

GO:0014070

GO:0016005

GO:0016241

GO:0016485

GO:0016787

GO:0021766

GO:0022414

GO:0030154

GO:0030163

GO:0030182

GO:0030216

GO:0030218

GO:0030220

GO:0030889

GO:0031264

GO:0031647

GO:0032025

GO:0032355

GO:0032496

GO:0034349

GO:0034612

GO:0035094

GO:0035556

GO:0042542

GO:0043025

GO:0043029

GO:0043065

GO:0043200

GO:0043226

GO:0043525

GO:0044346

GO:0044877

GO:0045165

GO:0045786

GO:0046007

GO:0048011

GO:0048856

GO:0050877

GO:0051146

GO:0051384

GO:0051402

GO:0051604

GO:0061713

GO:0070269

GO:0071407

GO:0071887

GO:0072734

GO:0097153

GO:0097190

GO:0097193

GO:0097194

GO:0097199

GO:0097200

GO:0098693

GO:0098772

GO:0098978

GO:0140096

GO:0140639

GO:1902004

GO:1904019

HMNXSV003052694

Hs.141125.0.A1_3p_at

ILMN_1731639

ILMN_2388155

PH_hs_0022563

TC04001807.hg

U13737_at

g4757911_3p_at

Participates

as a member of

Procaspases 2, 3 [cytosol] (Homo sapiens)

as a component of

CASP3(1-277) dimer [cytosol] (Homo sapiens)

Other forms of this molecule

CASP3(176-277) [cytosol]

CASP3(29-175) [cytosol]

CASP3(176-277) [nucleoplasm]

CASP3(29-175) [nucleoplasm]

Inferred To

Drice [cytosol] (Drosophila melanogaster)

CASP3 [cytosol] (Bos taurus)

CASP3 [cytosol] (Canis familiaris)

CASP3 [cytosol] (Gallus gallus)

Casp3 [cytosol] (Mus musculus)

Casp3 [cytosol] (Rattus norvegicus)

CASP3(1-277) [cytosol] (Sus scrofa)

casp3.2 [cytosol] (Xenopus tropicalis)

casp3a [cytosol] (Danio rerio)

ced-3 [cytosol] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

1619

OpenTargets

ENSG00000164305

ENSEMBL

ENST00000700100, ENST00000700101, ENST00000523916, ENST00000308394, ENSG00000164305, ENSP00000428929, ENSP00000514797, ENSP00000514798, ENSP00000311032

ZINC - FDA approved

CASP3_HUMAN

ZINC - Substances

CASP3_HUMAN

ZINC - Biogenic

CASP3_HUMAN

ZINC target

P42574

PRO

P42574

GlyGen

P42574

PDB

4QUD, 5IBP, 3ITN, 2XYP, 2XYH, 4QU8, 2DKO, 4QTY, 4QUJ, 1RHM, 4PS0, 2C2O, 5IBR, 2Y0B, 4EHL, 3PCX, 3DEK, 4EHA, 3PD1, 1PAU, 1RE1, 1NME, 2CJX, 2XZT, 5IAS, 4QUG, 4DCO, 5IBC, 7XN4, 2CJY, 4QUB, 4JR0, 4QUI, 4QU9, 2CNN, 1RHQ, 1RHU, 2CNK, 3EDQ, 2C1E, 1NMQ, 1QX3, 4QU0, 4EHK, 3GJQ, 3DEJ, 5IAJ, 3H0E, 5IAK, 3PD0, 2J31, 1CP3, 1GFW, 3GJT, 2CDR, 4QUL, 7XN6, 5I9T, 5IAR, 2C2K, 5IC4, 4JQZ, 4QUH, 4QUA, 4QTX, 1RHJ, 2CNL, 5IAB, 5IAG, 2XZD, 4EHF, 3DEI, 5I9B, 4JJE, 2J32, 1I3O, 2J33, 3GJS, 2H5I, 4QUE, 4PRY, 2XYG, 4DCP, 4JQY, 2C2M, 5IAN, 7XN5, 1RHK, 5IAE, 1RHR, 3DEH, 4DCJ, 2CNO, 4EHD, 3KJF, 4EHN, 1NMS, 4QU5, 4EHH, 2J30, 2H65, 3GJR, 2H5J

ZINC - Investigational

CASP3_HUMAN

IntEnz

3.4.22.56

HPA

ENSG00000164305-CASP3

GeneCards

CASP3

Pharos - Targets

P42574

ZINC - Predictions - Purchasable

CASP3_HUMAN

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.872	7
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.672	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.659	4
UniProt:O14727 APAF1	4	APAF1 [cytosol] (R-HSA-50099) APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [secretory granule lumen] (R-HSA-6801271)	0.653	7
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.644	3
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.623	2
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.609	2
UniProt:Q9Y243 AKT3	6	p-T305,S472-AKT3 [nucleoplasm] (R-HSA-3009365) p-T305,S472-AKT3 [cytosol] (R-HSA-3009367) p-S472-AKT3 [plasma membrane] (R-HSA-3009363) AKT3 [plasma membrane] (R-HSA-2976006) AKT3 [cytosol] (R-HSA-2976007) p-T305-AKT3 [cytosol] (R-HSA-3009370)	0.571	2
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.571	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.571	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9

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