Reactome | ITGB1 [plasma membrane]

ITGB1 [plasma membrane]

Stable Identifier

R-HSA-57596

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin beta-1, Fibronectin receptor beta subunit, CD29 antigen, Integrin VLA-4 beta subunit

Locations in the PathwayBrowser for interactor UniProt:P21333 FLNA

Expand all

External Reference Information

External Reference

UniProt:P05556 ITGB1

Gene Names

ITGB1, FNRB, MDF2, MSK12

Chain

signal peptide:1-20, chain:21-798

Reference Genes

BioGPS Gene:3688 ITGB1

COSMIC (genes):ITGB1 ITGB1

CTD Gene:3688 ITGB1

dbSNP Gene:3688 ITGB1

ENSEMBL:ENSG00000150093 ITGB1

HGNC:6153 ITGB1

KEGG Gene (Homo sapiens):3688 ITGB1

Monarch:3688 ITGB1

NCBI Gene:3688 ITGB1

OMIM:135630 ITGB1

UCSC:P05556 ITGB1

Reference Transcript

Other Identifiers

0004060372

0006130487

0007050465

11715728_a_at

11737219_a_at

11758189_s_at

11758276_s_at

1553530_a_at

1553678_a_at

211945_s_at

32808_at

3284190

3284191

3284192

3284193

3284198

3284201

3284202

3284203

3284204

3284205

3284206

3284207

3284208

3284210

3284211

3284213

3284214

3284215

3284217

3284218

3284221

3284230

3284232

3284255

3688

3822874

3852837

3852838

3852839

7932966

A_23_P104193

A_23_P104199

A_32_P95397

GE61911

GO:0000003

GO:0000082

GO:0000132

GO:0000278

GO:0000902

GO:0001618

GO:0001701

GO:0001708

GO:0001726

GO:0001968

GO:0002020

GO:0002042

GO:0002376

GO:0003674

GO:0003779

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005925

GO:0006810

GO:0006909

GO:0006950

GO:0006968

GO:0007010

GO:0007049

GO:0007155

GO:0007156

GO:0007159

GO:0007160

GO:0007161

GO:0007165

GO:0007229

GO:0007267

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008305

GO:0008354

GO:0008542

GO:0009056

GO:0009790

GO:0009897

GO:0009986

GO:0010710

GO:0010763

GO:0014704

GO:0015026

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016477

GO:0019221

GO:0019899

GO:0019960

GO:0021943

GO:0022607

GO:0023035

GO:0030027

GO:0030030

GO:0030032

GO:0030054

GO:0030154

GO:0030175

GO:0030183

GO:0030198

GO:0030335

GO:0031175

GO:0031410

GO:0031589

GO:0031594

GO:0031623

GO:0032154

GO:0032587

GO:0032991

GO:0033627

GO:0033631

GO:0034113

GO:0034665

GO:0034666

GO:0034667

GO:0034668

GO:0034674

GO:0034677

GO:0034678

GO:0034680

GO:0034681

GO:0035024

GO:0035633

GO:0035748

GO:0038023

GO:0040007

GO:0040011

GO:0042383

GO:0042470

GO:0042995

GO:0043065

GO:0043167

GO:0043197

GO:0043226

GO:0043235

GO:0043236

GO:0043547

GO:0044403

GO:0044877

GO:0045121

GO:0045202

GO:0045214

GO:0045296

GO:0045596

GO:0045766

GO:0046718

GO:0046872

GO:0046982

GO:0048333

GO:0048471

GO:0048646

GO:0048675

GO:0048813

GO:0048856

GO:0048870

GO:0050776

GO:0050839

GO:0050877

GO:0050900

GO:0050901

GO:0051726

GO:0051897

GO:0051951

GO:0055007

GO:0055037

GO:0055085

GO:0070062

GO:0071404

GO:0071438

GO:0071711

GO:0090303

GO:0097060

GO:0097386

GO:0098639

GO:0098978

GO:0099699

GO:0150003

GO:0150103

GO:1901979

GO:1903078

GO:1990782

GO:2000273

GO:2000811

Hs.287797.0.A1_3p_s_at

Hs2.287797.6.S1_3p_s_at

Hs2.287797.8.S1_3p_s_at

ILMN_1714820

ILMN_1723467

ILMN_1754233

ILMN_1784454

ILMN_2383934

PH_hs_0027353

TC10001163.hg

U33880_at

X07979_at

Participant Of

hasMember

hasComponent

input

ILK interacts with beta-1 integrin

output

SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

Other forms of this molecule

ITGB1 [endosome membrane]

Inferred To

pat-3 [plasma membrane] (Caenorhabditis elegans)

ITGB1 [plasma membrane] (Canis familiaris)

Itgb1 [plasma membrane] (Mus musculus)

Itgb1 [plasma membrane] (Rattus norvegicus)

itgb1 [plasma membrane] (Xenopus tropicalis)

mys [plasma membrane] (Drosophila melanogaster)

itgb1a [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002202.2, NP_391988.1, NP_596867.1

Target Pathogen

5b354852be737e166372eba8

OpenTargets

ENSG00000150093

HPA

ENSG00000150093-ITGB1

GeneCards

P05556

Ensembl

ENST00000423113, ENSP00000303351, ENSG00000150093, ENSP00000388694, ENST00000396033, ENST00000302278, ENSP00000379350

PRO

P05556

Orphanet

26402

PDB

3T9K, 4WK4, 3VI3, 1LHA, 4DX9, 4WK0, 4WJK, 3G9W, 3VI4, 1K11, 4WK2

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08648 ITGA5	1	ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.822	6
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712) FLNA [cytosol] (R-HSA-210019)	0.819	6
UniProt:P21926 CD9	4	CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [plasma membrane] (R-HSA-51717) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.69	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.678	4
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.678	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.662	7
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.648	10
UniProt:P78536 ADAM17	6	ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [plasma membrane] (R-HSA-179878)	0.609	2
UniProt:P26039	2	Tln1 [cytosol] (R-MMU-350713) Tln1 [extracellular region] (R-MMU-350693)	0.609	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	8
UniProt:Q9BYF1 ACE2	5	ACE2 [endocytic vesicle membrane] (R-HSA-9698958) ACE2(18-805) [plasma membrane] (R-HSA-2022344) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474)	0.57	4
UniProt:Q13387-4 MAPK8IP2			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:O60784-2 TOM1			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9BY76 ANGPTL4	2	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897)	0.544	2
UniProt:P32927 CSF2RB	6	CSF2RB [plasma membrane] (R-HSA-879960) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.544	5
UniProt:Q9Y490 TLN1	2	TLN1 [cytosol] (R-HSA-350713) TLN1 [extracellular region] (R-HSA-350693)	0.544	2
UniProt:P0DTC8 NS8			0.527	2
UniProt:P17813 EGLN			0.524	3
UniProt:P78423 CX3CL1	1	CX3CL1 [extracellular region] (R-HSA-373368)	0.524	2
UniProt:P05413 FABP3	1	FABP3 [cytosol] (R-HSA-5216066)	0.524	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	2
UniProt:P79114 MYO10			0.463	2
UniProt:P08962 CD63	3	CD63 [plasma membrane] (R-HSA-114583) CD63 [platelet dense granule membrane] (R-HSA-51683) CD63 [azurophil granule membrane] (R-HSA-6799157)	0.463	2
UniProt:P11279 LAMP1	3	LAMP1 [plasma membrane] (R-HSA-6806268) LAMP1 [azurophil granule membrane] (R-HSA-6799162) LAMP1 [ficolin-1-rich granule membrane] (R-HSA-6800966)	0.462	4
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2

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