Reactome | PRKAR1A [cytosol]

PRKAR1A [cytosol]

Stable Identifier

R-HSA-57836

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase type I-alpha regulatory chain, Tissue- specific extinguisher-1, TSE1

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
      - cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10644 PRKAR1A

Gene Names

PRKAR1A, PKR1, PRKAR1, TSE1

Chain

chain:1-381

Reference Genes

BioGPS Gene:5573 PRKAR1A

COSMIC (genes):PRKAR1A PRKAR1A

CTD Gene:5573 PRKAR1A

dbSNP Gene:5573 PRKAR1A

ENSEMBL:ENSG00000108946 PRKAR1A

HGNC:9388 PRKAR1A

KEGG:hsa:5573 PRKAR1A

Monarch:5573 PRKAR1A

NCBI Gene:5573 PRKAR1A

OMIM:188830 PRKAR1A

UCSC:P10644 PRKAR1A

Reference Transcript

Other Identifiers

11722007_a_at

11722008_a_at

11753791_s_at

16837326

200603_PM_at

200603_at

200604_PM_s_at

200604_s_at

200605_PM_s_at

200605_s_at

226_at

227_g_at

2346669

242482_PM_at

242482_at

3732886

3732887

3732888

3732889

3732890

3732891

3732892

3732893

3732894

3732895

3732896

3732897

3732898

3732899

3732900

3732901

3732902

3732903

3732904

3732905

3732906

3732907

3732908

3732909

3732910

3732911

3732912

3732913

3732914

3732915

3732916

3732917

3732918

3732919

3732920

3732921

3732922

3732923

3732926

41768_at

54729_at

5573

60224_at

8009457

80247_at

A_14_P113707

A_14_P127422

A_14_P136947

A_23_P433753

A_24_P245322

A_24_P356592

GE61216

GE87724

GO:0001707

GO:0001772

GO:0001932

GO:0003824

GO:0004862

GO:0005515

GO:0005737

GO:0005768

GO:0005771

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0005930

GO:0005952

GO:0006355

GO:0006357

GO:0007010

GO:0007189

GO:0007507

GO:0008603

GO:0010629

GO:0016020

GO:0016301

GO:0016740

GO:0019904

GO:0030552

GO:0031410

GO:0031588

GO:0031594

GO:0031625

GO:0032024

GO:0032991

GO:0034236

GO:0035556

GO:0043226

GO:0044853

GO:0045202

GO:0045214

GO:0046007

GO:0048856

GO:0060038

GO:0071377

GO:0097546

GO:0098772

GO:0098978

GO:0141162

HMNXSV003015567

HMNXSV003028511

HMNXSV003035036

Hs.183037.0.A3_3p_at

Hs.270431.0.A1_3p_at

ILMN_1738632

ILMN_2277077

ILMN_2389590

M33336_at

TC17000804.hg

TC17002330.hg

TC17002331.hg

g1526988_3p_a_at

g4506062_3p_a_at

Participates

as a member of

PKA regulatory subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAR1A [ciliary base]

PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]

PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]

Inferred To

PRKAR1A [cytosol] (Bos taurus)

PRKAR1A [cytosol] (Canis familiaris)

PRKAR1A [cytosol] (Danio rerio)

PRKAR1A [cytosol] (Gallus gallus)

PRKAR1A [cytosol] (Mus musculus)

PRKAR1A [cytosol] (Rattus norvegicus)

PRKAR1A [cytosol] (Sus scrofa)

PRKAR1A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_997637.1, NP_997636.1, NP_001263218.1, NP_001263219.1, XP_011523285.1, XP_011523286.1, NP_002725.1, XP_011523287.1, NP_001265362.1

Guide to Pharmacology - Targets

1472

ENSEMBL

ENST00000589480, ENSP00000464715, ENSP00000468106, ENST00000588178, ENSP00000465445, ENSP00000466459, ENST00000588188, ENSP00000466649, ENSP00000518555, ENSP00000464977, ENST00000585981, ENST00000586397, ENSP00000467311, ENST00000585427, ENSP00000465013, ENSP00000445625, ENST00000589017, ENST00000536854, ENST00000589228, ENST00000711037, ENST00000358598, ENST00000392711, ENSP00000351410, ENSP00000376475

OpenTargets

ENSG00000108946

HPA

ENSG00000108946-PRKAR1A

PRO

P10644

Pharos - Targets

P10644

GlyGen

P10644

Orphanet

PRKAR1A

PDB

5KJY, 5KJX, 5KJZ

HMDB Protein

HMDBP02560

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.958	17
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.671	4
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.659	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.643	3
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.623	5
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.564	2
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.556	3
UniProt:Q8N6U8 GPR161	2	GPR161 [ciliary membrane] (R-HSA-5610373) GPR161 [endocytic vesicle membrane] (R-HSA-5635021)	0.527	3
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.524	7
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.524	2

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