Reactome | PRKAR1B [cytosol]

PRKAR1B [cytosol]

Stable Identifier

R-HSA-57838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase type I-beta regulatory chain

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Metabolism (Homo sapiens)

- Integration of energy metabolism (Homo sapiens)
  - Glucagon signaling in metabolic regulation (Homo sapiens)
    - PKA activation in glucagon signalling (Homo sapiens)
      - cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
  - Regulation of insulin secretion (Homo sapiens)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
      - PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
        
        PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        PKA activation (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        PKA activation (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31321 PRKAR1B

Gene Names

PRKAR1B

Chain

initiator methionine:1, chain:2-381

Reference Genes

BioGPS Gene:5575 PRKAR1B

COSMIC (genes):PRKAR1B PRKAR1B

CTD Gene:5575 PRKAR1B

dbSNP Gene:5575 PRKAR1B

ENSEMBL:ENSG00000188191 PRKAR1B

HGNC:9390 PRKAR1B

KEGG Gene (Homo sapiens):5575 PRKAR1B

Monarch:5575 PRKAR1B

NCBI Gene:5575 PRKAR1B

OMIM:176911 PRKAR1B

UCSC:P31321 PRKAR1B

Reference Transcript

Other Identifiers

0006620377

1091_at

11743121_a_at

11743122_x_at

11745423_x_at

11759439_at

17054254

212555_at

212559_at

3034906

3034907

3034915

3034916

3034919

4048972

4049143

4049147

4049319

4049320

4049466

4049467

4049468

4049469

4049470

4049484

4049495

4049503

5575

80735_at

8137675

A_23_P83599

A_24_P216501

A_32_P72394

A_33_P3360675

GE518060

GE58041

GO:0000166

GO:0001932

GO:0003091

GO:0003674

GO:0004862

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005771

GO:0005829

GO:0005886

GO:0005929

GO:0005952

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007165

GO:0007267

GO:0007596

GO:0007611

GO:0008150

GO:0008603

GO:0010738

GO:0016020

GO:0016192

GO:0019899

GO:0030234

GO:0030552

GO:0031410

GO:0032991

GO:0034199

GO:0034236

GO:0042592

GO:0043167

GO:0043226

GO:0043949

GO:0045202

GO:0050804

GO:0050877

GO:0071377

GO:0097546

GO:0098685

GO:0098686

GO:0098693

GO:0098978

GO:2000480

Hs.1519.0.S1_3p_at

Hs.1519.0.S2_3p_at

ILMN_1674390

ILMN_3246219

M65066_at

PH_hs_0030870

PH_hs_0040590

TC07001074.hg

Participant Of

hasMember

PKA regulatory subunit [cytosol]

Other forms of this molecule

PRKAR1B [ciliary base]

Inferred To

prkar1b [cytosol] (Danio rerio)

PRKAR1B [cytosol] (Canis familiaris)

PRKAR1B [cytosol] (Gallus gallus)

PRKAR1B [cytosol] (Xenopus tropicalis)

kin-2 [cytosol] (Caenorhabditis elegans)

cgs1 [cytosol] (Schizosaccharomyces pombe)

Pka-R1 [cytosol] (Drosophila melanogaster)

BCY1 [cytosol] (Saccharomyces cerevisiae)

Prkar1b [cytosol] (Mus musculus)

cAMP-dependent protein kinase type I-beta regulatory subunit [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002726.1, NP_001158230.1, NP_001158232.1, NP_001158234.1, NP_001158231.1, NP_001158233.1

OpenTargets

ENSG00000188191

HPA

ENSG00000188191-PRKAR1B

GeneCards

P31321

Ensembl

ENST00000406797, ENST00000537384, ENST00000544935, ENST00000360274, ENSP00000385349, ENST00000403562, ENSG00000188191, ENSP00000353415, ENSP00000385749, ENSP00000440449, ENSP00000444487

PRO

P31321

Orphanet

23146

PDB

4DIN, 4F9K

HMDB Protein

HMDBP08137

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	3	PRKACA [cytosol] (R-HSA-57844) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936)	0.756	7
3',5'-cyclic AMP [ChEBI:17489]	1	cAMP [cytosol] (R-ALL-30389)	0.59	2
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.556	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.556	3
UniProt:P43080 GUCA1A	2	GUCA1A [cytosol] (R-HSA-55477) GUCA1A [photoreceptor disc membrane] (R-HSA-2586739)	0.556	3
UniProt:Q96G04 EEF2KMT	1	EEF2KMT [cytosol] (R-HSA-8876690)	0.556	3
UniProt:P38936 CDKN1A	5	p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585)	0.556	3
UniProt:P54646 PRKAA2	4	p-T172-PRKAA2 [cytosol] (R-HSA-200417) PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2