Reactome | PRKACG [cytosol]

PRKACG [cytosol]

Stable Identifier

R-HSA-57848

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase, gamma-catalytic subunit , PKA C-gamma

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P22612 PRKACG

Gene Names

PRKACG

Chain

initiator methionine:, chain:2-351

Reference Genes

BioGPS Gene:5568 PRKACG

COSMIC (genes):PRKACG PRKACG

CTD Gene:5568 PRKACG

dbSNP Gene:5568 PRKACG

ENSEMBL:ENSG00000165059 PRKACG

HGNC:9382 PRKACG

KEGG:hsa:5568 PRKACG

Monarch:5568 PRKACG

NCBI Gene:5568 PRKACG

OMIM:176893 PRKACG

UCSC:P22612 PRKACG

Reference Transcript

RefSeq:NM_002732.3 PRKACG

Other Identifiers

11735562_at

17094689

207228_PM_at

207228_at

3208641

3208642

3208643

3208644

3208645

3208646

3208647

3208648

36359_at

3852543

5568

8161615

ADDON002872.hg

A_23_P71926

GE577011

GO:0003014

GO:0003091

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0005952

GO:0006468

GO:0007283

GO:0008584

GO:0010737

GO:0016740

GO:0022414

GO:0034237

GO:0034380

GO:0043226

GO:0048856

GO:0065003

GO:0097546

GO:0106310

GO:0140096

HMNXSV003021164

ILMN_1808368

M34182_at

PH_hs_0009559

TC09001191.hg

g4506058_3p_at

Participates

as a candidate of

Protein kinase A catalytic subunit [cytosol] (Homo sapiens)

as a member of

PKA catalytic subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKACG [ciliary base]

PRKACG [nucleoplasm]

Inferred To

Dmel\CG12069 [cytosol] (Drosophila melanogaster)

Homologues of PRKACB [cytosol] (Drosophila melanogaster)

Homologues of PRKACB [cytosol] (Saccharomyces cerevisiae)

Prkaca [cytosol] (Mus musculus)

PRKACA [cytosol] (Bos taurus)

PRKACA [cytosol] (Caenorhabditis elegans)

PRKACA [cytosol] (Canis familiaris)

PRKACA [cytosol] (Danio rerio)

PRKACA [cytosol] (Drosophila melanogaster)

PRKACA [cytosol] (Rattus norvegicus)

PRKACA [cytosol] (Saccharomyces cerevisiae)

PRKACA [cytosol] (Schizosaccharomyces pombe)

PRKACA [cytosol] (Sus scrofa)

PRKACA [cytosol] (Xenopus tropicalis)

PRKACB [cytosol] (Drosophila melanogaster)

PRKACB [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_002723.2

Guide to Pharmacology - Targets

1478

ENSEMBL

ENSP00000366488, ENST00000377276

OpenTargets

ENSG00000165059

HPA

ENSG00000165059-PRKACG

PRO

P22612

Pharos - Targets

P22612

Orphanet

PRKACG

HMDB Protein

HMDBP01207

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.527	2
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.527	2
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q8N6U8 GPR161	2	GPR161 [ciliary membrane] (R-HSA-5610373) GPR161 [endocytic vesicle membrane] (R-HSA-5635021)	0.527	3