Reactome | PRKCB [cytosol]

PRKCB [cytosol]

Stable Identifier

R-HSA-58198

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, beta type , PKC-beta, PKC-B

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (Homo sapiens)
        
        PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)
        
        PRKCB [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated cell proliferation (Homo sapiens)
        
        PDK1 phosphorylates PKC (Homo sapiens)
        
        PKCA,PKCB,PKCD,PKCZ [cytosol] (Homo sapiens)
        
        PRKCB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05771 PRKCB

Gene Names

PRKCB, PKCB, PRKCB1

Chain

initiator methionine:1, chain:2-671

Reference Genes

BioGPS Gene:5579 PRKCB

COSMIC (genes):PRKCB PRKCB

CTD Gene:5579 PRKCB

dbSNP Gene:5579 PRKCB

ENSEMBL:ENSG00000166501 PRKCB

HGNC:9395 PRKCB

KEGG Gene (Homo sapiens):5579 PRKCB

Monarch:5579 PRKCB

NCBI Gene:5579 PRKCB

OMIM:176970 PRKCB

UCSC:P05771 PRKCB

Reference Transcript

Other Identifiers

0001850128

11721922_at

11721923_a_at

11721924_s_at

1216_at

1217_g_at

1336_s_at

160029_at

16817044

207957_PM_s_at

207957_s_at

209685_PM_s_at

209685_s_at

227817_PM_at

227817_at

227824_PM_at

227824_at

228795_PM_at

228795_at

3653124

3653125

3653126

3653127

3653128

3653167

3653179

3653181

3653190

3653191

3653195

3653197

3653203

3653212

3653213

3653216

3653217

3653218

3653222

3653233

3653234

3653235

3653236

3653237

3653238

3653239

3653240

3653241

3653242

3653243

54060_at

5579

62569_at

7994131

A_14_P119081

A_14_P138428

A_23_P206585

A_24_P935330

A_33_P3294533

GE59687

GE80408

GO:0000166

GO:0000278

GO:0002250

GO:0002376

GO:0003674

GO:0003682

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0004712

GO:0005080

GO:0005246

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006325

GO:0006357

GO:0006464

GO:0006468

GO:0006810

GO:0006816

GO:0006874

GO:0006915

GO:0007049

GO:0007077

GO:0007165

GO:0007267

GO:0008091

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0009058

GO:0010827

GO:0010829

GO:0015031

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0030374

GO:0030949

GO:0032991

GO:0034641

GO:0035403

GO:0035408

GO:0035556

GO:0042113

GO:0042393

GO:0042592

GO:0042953

GO:0043123

GO:0043167

GO:0043226

GO:0044305

GO:0045766

GO:0045893

GO:0046627

GO:0046872

GO:0048646

GO:0048856

GO:0050681

GO:0050853

GO:0050861

GO:0051092

GO:0051276

GO:0055085

GO:0061024

GO:0070062

GO:0071322

GO:0099171

GO:0099523

GO:0106310

GO:2000300

HMNXSV003020489

Hs.6749.0.A1_3p_at

Hs.6749.1.A1_3p_at

Hs.6749.1.A2_3p_at

ILMN_1713603

ILMN_1716563

ILMN_1806908

ILMN_3222974

ILMN_3299520

M18255_cds2_s_at

PH_hs_0023926

PH_hs_0039907

TC16000260.hg

X06318_at

X07109_at

g189968_3p_at

g4506068_3p_a_at

Participates

as a member of

as an output of

PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)

as an input of

PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)

Other forms of this molecule

PRKCB [plasma membrane]

p-T500-PRKCB [cytosol]

p-T500,T642,S661-PRKCB [cytosol]

p-T500,T642,S661-PRKCB [nucleoplasm]

Inferred To

PKC1 [cytosol] (Saccharomyces cerevisiae)

prkcb [cytosol] (Xenopus tropicalis)

Prkcb [cytosol] (Mus musculus)

Prkcb [cytosol] (Rattus norvegicus)

pck2 [cytosol] (Schizosaccharomyces pombe)

pkc-2 [cytosol] (Caenorhabditis elegans)

Pkc53E [cytosol] (Drosophila melanogaster)

prkcbb [cytosol] (Danio rerio)

PRKCB [cytosol] (Bos taurus)

PRKCB [cytosol] (Canis familiaris)

PRKCB [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_002729.2, NP_997700.1

Guide to Pharmacology - Targets

1483

OpenTargets

ENSG00000166501

ZINC - FDA approved

KPCB_HUMAN

ZINC - Substances

KPCB_HUMAN

ZINC target

P05771

ZINC - Biogenic

KPCB_HUMAN

PRO

P05771

PDB

2I0E

ZINC - Investigational

KPCB_HUMAN

IntEnz

2.7.11.13

GeneCards

P05771

HPA

ENSG00000166501-PRKCB

Ensembl

ENST00000321728, ENSG00000166501, ENSP00000496129, ENSP00000318315, ENST00000643927

Pharos - Targets

P05771

ZINC - Predictions - Purchasable

KPCB_HUMAN

Orphanet

27401

HMDB Protein

HMDBP01372

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEM2 SHCBP			0.564	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.547	2
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.527	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2