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PRKCB [cytosol]
Stable Identifier
R-HSA-58198
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, beta type , PKC-beta, PKC-B
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (Homo sapiens)
PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)
PRKCB [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Activation of conventional Protein Kinase C (Homo sapiens)
Protein Kinase C, conventional [cytosol] (Homo sapiens)
PRKCB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)
PRKCB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PDK1 phosphorylates PKC (Homo sapiens)
PKCA,PKCB,PKCD,PKCZ [cytosol] (Homo sapiens)
PRKCB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05771 PRKCB
Gene Names
PRKCB, PKC-beta, PKCB, PRKCB1
Chain
initiator methionine:, chain:2-671
Reference Genes
BioGPS Gene:5579 PRKCB
COSMIC (genes):PRKCB PRKCB
CTD Gene:5579 PRKCB
dbSNP Gene:5579 PRKCB
ENSEMBL:ENSG00000166501 PRKCB
ENSEMBL_homo_sapiens_GENE:ENSG00000166501.14 PRKCB
HGNC:9395 PRKCB
KEGG Gene (Homo sapiens):5579 PRKCB
Monarch:5579 PRKCB
NCBI Gene:5579 PRKCB
OMIM:176970 PRKCB
UCSC:P05771 PRKCB
Reference Transcript
RefSeq:NM_002738.6 PRKCB
RefSeq:NM_212535.2 PRKCB
Other Identifiers
11721922_at
11721923_a_at
11721924_s_at
1216_at
1217_g_at
1336_s_at
160029_at
16817044
207957_PM_s_at
207957_s_at
209685_PM_s_at
209685_s_at
227817_PM_at
227817_at
227824_PM_at
227824_at
228795_PM_at
228795_at
3653124
3653125
3653126
3653127
3653128
3653167
3653179
3653181
3653190
3653191
3653195
3653197
3653203
3653212
3653213
3653216
3653217
3653218
3653222
3653233
3653234
3653235
3653236
3653237
3653238
3653239
3653240
3653241
3653242
3653243
54060_at
5579
62569_at
7994131
A_14_P119081
A_14_P138428
A_23_P206585
A_24_P935330
A_33_P3294533
GE59687
GE80408
GO:0000166
GO:0000278
GO:0002250
GO:0002376
GO:0003682
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005080
GO:0005246
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006816
GO:0006874
GO:0006915
GO:0007077
GO:0007165
GO:0007207
GO:0008091
GO:0008270
GO:0009410
GO:0009749
GO:0010827
GO:0010829
GO:0012501
GO:0014059
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018894
GO:0023052
GO:0030374
GO:0030949
GO:0031526
GO:0032024
GO:0033280
GO:0035403
GO:0035556
GO:0036211
GO:0040008
GO:0042113
GO:0042393
GO:0042488
GO:0042953
GO:0043123
GO:0043226
GO:0043687
GO:0044305
GO:0045471
GO:0045766
GO:0045893
GO:0046627
GO:0046872
GO:0048856
GO:0050681
GO:0050853
GO:0050861
GO:0055065
GO:0055085
GO:0061024
GO:0070062
GO:0071322
GO:0080090
GO:0098772
GO:0099171
GO:0099523
GO:0106310
GO:0140096
GO:0140110
GO:2000300
HMNXSV003020489
Hs.6749.0.A1_3p_at
Hs.6749.1.A1_3p_at
Hs.6749.1.A2_3p_at
ILMN_1713603
ILMN_1716563
ILMN_1806908
M18255_cds2_s_at
PH_hs_0023926
PH_hs_0039907
TC16000260.hg
X06318_at
X07109_at
g189968_3p_at
g4506068_3p_a_at
Participates
as a member of
Protein Kinase C, conventional [cytosol] (Homo sapiens)
PKCA,PKCB,PKCD,PKCZ [cytosol] (Homo sapiens)
as an output of
PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)
as an input of
PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)
Other forms of this molecule
PRKCB [plasma membrane]
p-T500-PRKCB [cytosol]
p-T500,T642,S661-PRKCB [cytosol]
p-T500,T642,S661-PRKCB [nucleoplasm]
Inferred To
Homologues of PRKCB [cytosol]
(Dictyostelium discoideum)
Homologues of PRKCB [cytosol]
(Drosophila melanogaster)
Homologues of PRKCB [cytosol]
(Schizosaccharomyces pombe)
PRKCB [cytosol]
(Bos taurus)
PRKCB [cytosol]
(Caenorhabditis elegans)
PRKCB [cytosol]
(Canis familiaris)
PRKCB [cytosol]
(Danio rerio)
PRKCB [cytosol]
(Dictyostelium discoideum)
PRKCB [cytosol]
(Drosophila melanogaster)
PRKCB [cytosol]
(Gallus gallus)
PRKCB [cytosol]
(Mus musculus)
PRKCB [cytosol]
(Rattus norvegicus)
PRKCB [cytosol]
(Saccharomyces cerevisiae)
PRKCB [cytosol]
(Schizosaccharomyces pombe)
PRKCB [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002729.2
,
NP_997700.1
Guide to Pharmacology - Targets
1483
OpenTargets
ENSG00000166501
ZINC - Substances
KPCB_HUMAN
ZINC target
P05771
ZINC - Biogenic
KPCB_HUMAN
PRO
P05771
PDB
2I0E
ZINC - Investigational
KPCB_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000166501-PRKCB
GeneCards
P05771
Ensembl
ENSP00000318315
,
ENSG00000166501
,
ENSP00000496129
,
ENST00000321728
,
ENST00000643927
Pharos - Targets
P05771
ZINC - Predictions - Purchasable
KPCB_HUMAN
HMDB Protein
HMDBP01372
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NEM2 SHCBP
0.564
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.547
2
UniProt:P17252 PRKCA
8
PRKCA [nucleoplasm]
(R-HSA-450530)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
0.527
3
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD [cytosol]
(R-HSA-58200)
0.527
2
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.508
2
UniProt:Q9NRW3 APOBEC3C
1
APOBEC3C [nucleoplasm]
(R-HSA-8874997)
0.483
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
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