Reactome | PRKCZ [cytosol]

PRKCZ [cytosol]

Stable Identifier

R-HSA-58218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKC-zeta, Protein kinase C, zeta type

Locations in the PathwayBrowser for interactor UniProt:P40337

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Extra-nuclear estrogen signaling (Homo sapiens)
      - Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
        
        PDPK1 binds PRKCZ (Homo sapiens)
        
        PRKCZ [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05513 PRKCZ

Gene Names

PRKCZ, PKC2

Chain

chain:1-592

Reference Genes

BioGPS Gene:5590 PRKCZ

COSMIC (genes):PRKCZ PRKCZ

CTD Gene:5590 PRKCZ

dbSNP Gene:5590 PRKCZ

ENSEMBL:ENSG00000067606 PRKCZ

HGNC:9412 PRKCZ

KEGG Gene (Homo sapiens):5590 PRKCZ

Monarch:5590 PRKCZ

NCBI Gene:5590 PRKCZ

OMIM:176982 PRKCZ

UCSC:Q05513 PRKCZ

Reference Transcript

Other Identifiers

0002850619

11716375_s_at

11739001_s_at

11747845_x_at

202178_at

2316269

2316275

2316279

2316280

2316282

2316285

2316297

2316298

2316299

2316300

2316303

2316304

2316321

2316322

2316323

2316324

2316325

2316326

2316327

2316328

2316329

362_at

4054482

4054508

4054510

4054511

4054530

4054536

5590

7897044

A_23_P51187

GE60356

GO:0000166

GO:0000226

GO:0000902

GO:0001725

GO:0001954

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005923

GO:0005938

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0007166

GO:0007179

GO:0007267

GO:0007616

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0014069

GO:0015031

GO:0015459

GO:0016020

GO:0016301

GO:0016310

GO:0016324

GO:0016363

GO:0016477

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0030010

GO:0030054

GO:0030154

GO:0030705

GO:0031252

GO:0031333

GO:0031410

GO:0031584

GO:0031982

GO:0032148

GO:0032733

GO:0032736

GO:0032753

GO:0032754

GO:0032869

GO:0034613

GO:0034641

GO:0035556

GO:0035748

GO:0040007

GO:0040011

GO:0043066

GO:0043167

GO:0043203

GO:0043226

GO:0043231

GO:0043274

GO:0043560

GO:0044877

GO:0045121

GO:0045179

GO:0045630

GO:0046627

GO:0046628

GO:0046872

GO:0047496

GO:0048471

GO:0048856

GO:0048870

GO:0050732

GO:0050806

GO:0050877

GO:0051092

GO:0051222

GO:0051346

GO:0051899

GO:0060081

GO:0060291

GO:0065003

GO:0070062

GO:0070374

GO:0070528

GO:0071889

GO:0072659

GO:0098685

GO:0098696

GO:0098978

GO:1990138

GO:2000463

GO:2000553

HMNXSV003020065

HMNXSV003056064

ILMN_1662155

ILMN_1697267

ILMN_1775050

ILMN_1807953

ILMN_2386982

PH_hs_0028347

Z15108_at

g10864649_3p_at

Participates

as an input of

PDPK1 binds PRKCZ (Homo sapiens)

as a component of

PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)

as a member of

PKCA,PKCB,PKCD,PKCZ [cytosol] (Homo sapiens)

Other forms of this molecule

p-T410-PRKCZ [cytosol]

p-T410,T563-PRKCZ [cytosol]

PRKCZ [cell junction]

pS, p-T410-PRKCZ [cytosol]

Inferred To

PKC1 [cytosol] (Saccharomyces cerevisiae)

pck1 [cytosol] (Schizosaccharomyces pombe)

pkc-3 [cytosol] (Caenorhabditis elegans)

Homologues of PRKCZ [cytosol] (Schizosaccharomyces pombe)

pck2 [cytosol] (Schizosaccharomyces pombe)

PRKCZ [cytosol] (Bos taurus)

PRKCZ [cytosol] (Canis familiaris)

PRKCZ [cytosol] (Gallus gallus)

PRKCZ [cytosol] (Sus scrofa)

prkcz [cytosol] (Danio rerio)

Prkcz [cytosol] (Mus musculus)

Prkcz [cytosol] (Rattus norvegicus)

aPKC [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_016857288.1, NP_002735.3, NP_001028753.1, NP_001028754.1, NP_001229803.1

OpenTargets

ENSG00000067606

ZINC - Substances

KPCZ_HUMAN

ZINC - Biogenic

KPCZ_HUMAN

ZINC target

Q05513

PRO

Q05513

ZINC - Investigational

KPCZ_HUMAN

IntEnz

2.7.11.13

HPA

ENSG00000067606-PRKCZ

GeneCards

Q05513

Ensembl

ENST00000378567, ENST00000461106, ENSP00000367830, ENST00000400921, ENSP00000383712, ENSP00000426412, ENSG00000067606

ZINC - Predictions - Purchasable

KPCZ_HUMAN

HMDB Protein

HMDBP01374

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYG5 PARD6B	2	PARD6B [cytosol] (R-HSA-419973) PARD6B [plasma membrane] (R-HSA-418193)	0.935	13
UniProt:Q9NPB6 PARD6A	4	p-S345-PARD6A [plasma membrane] (R-HSA-2134533) PARD6A [cell junction] (R-HSA-2134480) PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001)	0.872	8
UniProt:P41743 PRKCI	3	PRKCI [cytosol] (R-HSA-58206) PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [plasma membrane] (R-HSA-420005)	0.802	7
UniProt:Q9BYG4 PARD6G	2	PARD6G [cytosol] (R-HSA-419967) PARD6G [plasma membrane] (R-HSA-418192)	0.802	6
UniProt:Q15334 L2GL1			0.725	6
UniProt:Q07021 C1QBP	3	C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123) C1QBP [cytosol] (R-HSA-9645690)	0.669	4
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.612	6
UniProt:P49757-1 NUMB			0.602	4
UniProt:Q04759 PRKCQ	9	p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216)	0.581	3
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.544	2
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.536	2
UniProt:Q6P1M3 L2GL2			0.527	4
UniProt:O75323 NIPSNAP2	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.527	3
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.527	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2
UniProt:O95999 BCL10	3	BCL10 [cytosol] (R-HSA-202447) K48polyUb-BCL10 [cytosol] (R-HSA-8939329) p-BCL10 [cytosol] (R-HSA-202488)	0.518	3
UniProt:P40337 VHL	3	VHL [nucleoplasm] (R-HSA-1234127) SUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [cytosol] (R-HSA-391423)	0.463	3

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