Reactome | PRKCZ [cytosol]

PRKCZ [cytosol]

Stable Identifier

R-HSA-58218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKC-zeta, Protein kinase C, zeta type

Locations in the PathwayBrowser for interactor UniProt:Q9NPB6 PARD6A

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Extra-nuclear estrogen signaling (Homo sapiens)
      - Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
        
        PDPK1 binds PRKCZ (Homo sapiens)
        
        PRKCZ [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05513 PRKCZ

Gene Names

PRKCZ, PKC2

Chain

chain:1-592

Reference Genes

BioGPS Gene:5590 PRKCZ

COSMIC (genes):PRKCZ PRKCZ

CTD Gene:5590 PRKCZ

dbSNP Gene:5590 PRKCZ

ENSEMBL:ENSG00000067606 PRKCZ

HGNC:9412 PRKCZ

KEGG:hsa:5590 PRKCZ

Monarch:5590 PRKCZ

NCBI Gene:5590 PRKCZ

OMIM:176982 PRKCZ

UCSC:Q05513 PRKCZ

Reference Transcript

Participates

as a candidate of

Keratinocyte PKCs [cytosol] (Homo sapiens)

as an input of

PDPK1 binds PRKCZ (Homo sapiens)

as a component of

PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)

as a member of

PKCA,PKCB,PKCD,PKCZ [cytosol] (Homo sapiens)

Other forms of this molecule

PRKCZ [cell junction]

p-T410-PRKCZ [cytosol]

p-T410,T563-PRKCZ [cytosol]

pS, p-T410-PRKCZ [cytosol]

Inferred To

Homologues of PRKCZ [cytosol] (Dictyostelium discoideum)

Homologues of PRKCZ [cytosol] (Schizosaccharomyces pombe)

PRKCZ [cytosol] (Bos taurus)

PRKCZ [cytosol] (Caenorhabditis elegans)

PRKCZ [cytosol] (Canis familiaris)

PRKCZ [cytosol] (Dictyostelium discoideum)

PRKCZ [cytosol] (Drosophila melanogaster)

PRKCZ [cytosol] (Gallus gallus)

PRKCZ [cytosol] (Mus musculus)

PRKCZ [cytosol] (Rattus norvegicus)

PRKCZ [cytosol] (Saccharomyces cerevisiae)

PRKCZ [cytosol] (Schizosaccharomyces pombe)

PRKCZ [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001028754.1, NP_001028753.1, NP_001229803.1, NP_002735.3, XP_016857288.1

Guide to Pharmacology - Targets

1491

ENSEMBL

ENSP00000383712, ENSG00000067606, ENSP00000426412, ENST00000400921, ENST00000461106, ENSP00000367830, ENST00000378567

OpenTargets

ENSG00000067606

ZINC - Substances

KPCZ_HUMAN

ZINC - Biogenic

KPCZ_HUMAN

ZINC target

Q05513

PRO

Q05513

GlyGen

Q05513

ZINC - Investigational

KPCZ_HUMAN

IntEnz

2.7.11.13

HPA

ENSG00000067606-PRKCZ

GeneCards

PRKCZ

Pharos - Targets

Q05513

ZINC - Predictions - Purchasable

KPCZ_HUMAN

HMDB Protein

HMDBP01374

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.949	18
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.906	10
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.886	9
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.886	10
UniProt:Q15334 L2GL1			0.837	9
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.725	6
UniProt:O75323 GBAS	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.725	5
UniProt:Q6P1M3 L2GL2			0.725	8
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.669	4
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.612	6
UniProt:P49757-1 NUMB			0.602	4
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.581	3
UniProt:P14598 NCF1	4	p-6S-NCF1 [phagolysosome] (R-HSA-1996220) NCF1 [cytosol] (R-HSA-1222296) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.544	2
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.536	2
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	4
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.527	2
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	3
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.527	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	2
UniProt:O43852 CALU	3	CALU [extracellular region] (R-HSA-350739) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [endoplasmic reticulum lumen] (R-HSA-350695)	0.527	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.524	2
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.518	3
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.463	3