Reactome | MAD2L2 [nucleoplasm]

MAD2L2 [nucleoplasm]

Stable Identifier

R-HSA-59092

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HREV7, Mitotic spindle assembly checkpoint protein MAD2B (MAD2-like 2) (hREV7), Mitotic spindle assembly checkpoint protein MAD2B, MAD2-like 2, hREV7

Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1

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External Reference Information

External Reference

UniProt:Q9UI95 MAD2L2

Gene Names

MAD2L2, MAD2B, REV7

Chain

chain:1-211

Reference Genes

BioGPS Gene:10459 MAD2L2

COSMIC (genes):MAD2L2 MAD2L2

CTD Gene:10459 MAD2L2

dbSNP Gene:10459 MAD2L2

ENSEMBL:ENSG00000116670 MAD2L2

ENSEMBL_homo_sapiens_GENE:ENSG00000116670.16 MAD2L2

HGNC:6764 MAD2L2

KEGG Gene (Homo sapiens):10459 MAD2L2

Monarch:10459 MAD2L2

NCBI Gene:10459 MAD2L2

OMIM:604094 MAD2L2

UCSC:Q9UI95 MAD2L2

Reference Transcript

Other Identifiers

10459

11722434_a_at

16681749

223234_PM_at

223234_at

2396782

2396783

2396784

2396785

2396786

2396789

2396791

2396792

2396794

2396795

2396796

2396797

2396798

2396799

2396800

56235_at

7912481

A_23_P23206

GE58399

GO:0000122

GO:0000278

GO:0000785

GO:0001558

GO:0002208

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005694

GO:0005737

GO:0005819

GO:0005856

GO:0006281

GO:0006302

GO:0006310

GO:0006351

GO:0006355

GO:0006974

GO:0007010

GO:0007015

GO:0007049

GO:0007059

GO:0007094

GO:0007155

GO:0008432

GO:0010628

GO:0010718

GO:0010719

GO:0010944

GO:0016035

GO:0023052

GO:0030154

GO:0030163

GO:0030198

GO:0032200

GO:0033138

GO:0035861

GO:0036211

GO:0042177

GO:0042276

GO:0042772

GO:0043226

GO:0043247

GO:0043433

GO:0045830

GO:0045893

GO:0048856

GO:0051301

GO:0061629

GO:0090090

GO:0140014

GO:1901203

GO:1904667

GO:2000042

GO:2000048

GO:2000678

GO:2001034

HMNXSV003029504

ILMN_1669550

PH_hs_0001706

TC01002200.hg

g6642734_3p_at

Participates

as an input of

Formation of Pol zeta complex (Homo sapiens)

as a component of

POLZ [nucleoplasm] (Homo sapiens)

Inferred To

mad2l2 [nucleoplasm] (Danio rerio)

mad2l2 [nucleoplasm] (Dictyostelium discoideum)

mad2l2 [nucleoplasm] (Xenopus tropicalis)

rev7 [nucleoplasm] (Schizosaccharomyces pombe)

MAD2L2 [nucleoplasm] (Bos taurus)

MAD2L2 [nucleoplasm] (Canis familiaris)

MAD2L2 [nucleoplasm] (Gallus gallus)

MAD2L2 [nucleoplasm] (Plasmodium falciparum)

MAD2L2 [nucleoplasm] (Sus scrofa)

Ghost homologue of MAD2L2 [nucleoplasm] (Caenorhabditis elegans)

PolZ2 [nucleoplasm] (Drosophila melanogaster)

REV7 [nucleoplasm] (Saccharomyces cerevisiae)

Mad2l2 [nucleoplasm] (Mus musculus)

Mad2l2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011538809.1, NP_006332.3, NP_001120797.1

OpenTargets

ENSG00000116670

GeneCards

Q9UI95

HPA

ENSG00000116670-MAD2L2

Ensembl

ENSP00000365882, ENST00000456915, ENSG00000116670, ENSP00000365855, ENSP00000235310, ENST00000376667, ENST00000235310, ENST00000376692, ENSP00000400982

PRO

Q9UI95

Pharos - Targets

Q9UI95

Orphanet

25126

PDB

7L9P, 5XPU, 6WWA, 5XPT, 6WS0, 6M7A, 6WS5, 6NIF, 6BI7, 6BC8, 4GK0, 3ABD, 3VU7, 4EXT, 6BCD, 4GK5, 6K07, 6KEA, 3ABE, 6WW9, 6VE5, 6K08, 6KTO, 6M7B

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JM3 CHAP1			0.816	6
UniProt:Q6ZNX1 SHLD3			0.65	7
UniProt:P10321 HLA-C	8	HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983044) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983354) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane] (R-HSA-983387) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (R-HSA-199595) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (R-HSA-1236799) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (R-HSA-8863915) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236760) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane] (R-HSA-6803292)	0.643	3
UniProt:O60673 REV3L	1	REV3L [nucleoplasm] (R-HSA-110278)	0.639	5
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.635	3
UniProt:P18011 SCTE			0.602	7
UniProt:Q9UBZ9 REV1	1	REV1 [nucleoplasm] (R-HSA-3006726)	0.591	4
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q9C029 TRIM7			0.556	3
UniProt:P15884-3 TCF4			0.556	3
UniProt:O75140-2 DEPDC5			0.556	3
UniProt:Q9H0C1 ZMY12			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q8NB15 ZN511			0.556	3
UniProt:O15499 GSC2			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q13422 IKZF1			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q9H1P6 CMIP1			0.556	3
UniProt:Q86YS3 RFIP4			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q6MZQ0 PRR5L			0.556	3
UniProt:A8K8P3-4 SFI1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q13554 CAMK2B	5	p-T287-CAMK2B [plasma membrane] (R-HSA-432791) p-T287-CAMK2B [nucleoplasm] (R-HSA-444787) p-T287-CAMK2B [endocytic vesicle membrane] (R-HSA-417009) CAMK2B [cytosol] (R-HSA-9611360) p-T287-CAMK2B [cytosol] (R-HSA-445371)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q8TBB0 THAP6			0.556	3
UniProt:Q9NTX9 F217B			0.556	3
UniProt:Q9C0B1-2 Q9C0B12			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q9UPG8 PLAL2			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q7L273 KCTD9			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:O75688-3 PPM1B			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q96NG5 ZNF558	1	ZNF558 [nucleoplasm] (R-HSA-1973893)	0.556	3
UniProt:P30550 GRPR	1	GRPR [plasma membrane] (R-HSA-375363)	0.527	2
UniProt:Q8TBP5 F174A			0.527	2
UniProt:P09989 RIPT			0.527	2
UniProt:Q9UQV4 LAMP3			0.527	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:P78347 GTF2I			0.527	2
UniProt:Q9NRB3 CHST12	1	CHST12 [Golgi membrane] (R-HSA-1971456)	0.527	2
UniProt:P15260 IFNGR1	2	IFNGR1 [plasma membrane] (R-HSA-629623) p-Y457-IFNGR1 [plasma membrane] (R-HSA-873798)	0.527	2
UniProt:Q5VT40 FA78B			0.527	2
UniProt:Q9HBV2 SACA1			0.527	2
UniProt:P06028 GYPB	1	GYPB [plasma membrane] (R-HSA-8867209)	0.527	2
UniProt:P13598 ICAM2	1	ICAM2 [plasma membrane] (R-HSA-197852)	0.527	2
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.524	2
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.524	2
UniProt:Q15645 PCH2			0.488	2
UniProt:P14079 TAX			0.488	2

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