Reactome | MAPK3 [cytosol]

MAPK3 [cytosol]

Stable Identifier

R-HSA-59284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK1, Mitogen-activated protein kinase 3 (EC 2.7.1.-) (Extracellular signal- regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein-2 kinase), Mitogen-activated protein kinase 3 , Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule- associated protein-2 kinase

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Locations in the PathwayBrowser for interactor UniProt:Q49AJ0-4 Q49AJ04

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Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF-independent MAPK1/3 activation (Homo sapiens)
      - MAPK3 (ERK1) activation (Homo sapiens)
        
        MAP2K1 binds MAPK3 (Homo sapiens)
        
        MAPK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P27361 MAPK3

Gene Names

MAPK3, ERK1, PRKM3

Chain

initiator methionine:, chain:2-379

Reference Genes

BioGPS Gene:5595 MAPK3

COSMIC (genes):MAPK3 MAPK3

CTD Gene:5595 MAPK3

dbSNP Gene:5595 MAPK3

ENSEMBL:ENSG00000102882 MAPK3

HGNC:6877 MAPK3

KEGG:hsa:5595 MAPK3

Monarch:5595 MAPK3

NCBI Gene:5595 MAPK3

OMIM:601795 MAPK3

UCSC:P27361 MAPK3

Reference Transcript

Participates

as a member of

as a component of

as an input of

MAP2K1 binds MAPK3 (Homo sapiens)

Other forms of this molecule

p-T202,Y204-MAPK3 [nucleoplasm]

p-T202,Y204-MAPK3 [cytosol]

MAPK3 [nucleoplasm]

p-T202-MAPK3 [cytosol]

MAPK3 [endoplasmic reticulum lumen]

Inferred To

MAPK3 [cytosol] (Bos taurus)

MAPK3 [cytosol] (Caenorhabditis elegans)

MAPK3 [cytosol] (Canis familiaris)

MAPK3 [cytosol] (Danio rerio)

MAPK3 [cytosol] (Dictyostelium discoideum)

MAPK3 [cytosol] (Drosophila melanogaster)

MAPK3 [cytosol] (Mus musculus)

MAPK3 [cytosol] (Plasmodium falciparum)

MAPK3 [cytosol] (Rattus norvegicus)

MAPK3 [cytosol] (Saccharomyces cerevisiae)

MAPK3 [cytosol] (Schizosaccharomyces pombe)

MAPK3 [cytosol] (Sus scrofa)

Homologues of MAPK3 [cytosol] (Saccharomyces cerevisiae)

Homologues of MAPK3 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001035145.1, NP_002737.2, NP_001103361.1

Guide to Pharmacology - Targets

1494

OpenTargets

ENSG00000102882

ENSEMBL

ENST00000263025, ENST00000395199, ENSG00000102882, ENST00000395202, ENST00000322266, ENSP00000327293, ENSP00000263025, ENSP00000378628, ENSP00000378625

ZINC - FDA approved

MK03_HUMAN

ZINC - Substances

MK03_HUMAN

ZINC - Biogenic

MK03_HUMAN

ZINC target

P27361

PRO

P27361

PDB

4QTB, 2ZOQ, 6GES

ZINC - Investigational

MK03_HUMAN

ZINC - Metabolites

MK03_HUMAN

GeneCards

MAPK3

HPA

ENSG00000102882-MAPK3

Pharos - Targets

P27361

ZINC - Predictions - Purchasable

MK03_HUMAN

HMDB Protein

HMDBP01263

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.919	10
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.774	8
UniProt:Q16828 DUSP6	2	DUSP6 [cytosol] (R-HSA-5675343) DUSP6 [nucleoplasm] (R-HSA-2871619)	0.744	5
UniProt:Q15121 PEA15	1	PEA15 [cytosol] (R-HSA-5675204)	0.743	5
UniProt:Q15349 RPS6KA2	7	p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) RPS6KA2 [cytosol] (R-HSA-444252) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [nucleoplasm] (R-HSA-199861)	0.706	5
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.706	3
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.697	5
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300)	0.691	5
UniProt:Q62132 PTPRR			0.667	3
UniProt:P54829 PTPN5	1	PTPN5 [nucleoplasm] (R-HSA-9008908)	0.643	3
UniProt:P23467 PTPRB	3	PTPRB [tertiary granule membrane] (R-HSA-6801032) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [specific granule membrane] (R-HSA-6799638)	0.623	2
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.623	2
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.618	5
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.615	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.615	3
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.571	2
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.558	2
UniProt:Q9EPI6 NSMF			0.558	2
UniProt:Q9ULW8 PADI3	2	PADI3 [cytosol] (R-HSA-1183173) PADI3 [nucleoplasm] (R-HSA-6793444)	0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q9HCU0 CD248			0.556	3
UniProt:Q49AJ0-4 Q49AJ04			0.556	3
UniProt:Q8N490 PNKD			0.556	4
UniProt:Q96HT8 MR1L1			0.556	3
UniProt:Q96NJ5 KLH32			0.556	3
UniProt:Q9UK32 RPS6KA6	5	p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm] (R-HSA-444293) p-T368,S372,S389,T581,S742-RPS6KA6 [cytosol] (R-HSA-9619985) p-S232,T368,S372,S389,T581,S742-RPS6KA6 [cytosol] (R-HSA-9619870) p-T368,S372,T581-RPS6KA6 [cytosol] (R-HSA-9619958) RPS6KA6 [cytosol] (R-HSA-444266)	0.547	2
UniProt:Q9H8X9 ZDHHC11	1	ZDHHC11 [Golgi membrane] (R-HSA-9774147)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	3
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	2
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.527	2
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.527	3
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.527	2
UniProt:Q7Z7G2 CPLX4			0.527	2
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.527	2
UniProt:Q92576 PHF3			0.527	2
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.499	2

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