Phosphorylation of PLCgamma by Netrin-1

Stable Identifier
R-HSA-593690
Type
Reaction [omitted]
Species
Homo sapiens
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Netrin-1-DCC mediated signaling rapidly phosphorylates PLCgamma. Netrin-1 mediated PLC activation depends on recruitment of PITPalpha to DCC. Stimulation of PLC signaling and hydrolysis of PIP2 by netrin-1 in neurons is time-dependent, with a maximal activity observed within 15 min of netrin-1 stimulation.

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